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Filtering by: Subject Tetrachlorodibenzodioxin -- Toxicology Decade 2000-2009

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:

Funatake, Castle J.

Abstract:

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...

Resource Type:

Dissertation

Full Text:

degree of Doctor of Philosophy in Toxicology presented on May 1. 2006. Title: The Influence of Aryl
Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

Creator:

Marshall, Nikki B.

Abstract:

The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...

Resource Type:

Dissertation