Index Catalog // ScholarsArchive@OSU

A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

Creator:: Geisler, Mark S.
Abstract:: Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
Resource Type:: Honors College Thesis

A Bayesian Treatise on the Replication Crisis in Science

Creator:: Gibson, True E.
Abstract:: Over the past decade, it has come to light that many published scientific findings cannot be reproduced. This has led to the replication crisis in science. Many researchers feel that they can no longer trust much of what they read in scientific journals, and the public is becoming ever more...
Resource Type:: Honors College Thesis

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Creator:: Rouches, Miles V.
Abstract:: The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
Resource Type:: Honors College Thesis

Artistic Interpretation of the Significance of Human Breast Cancer Cell Vinculin Distribution in Different Extracellular Matrix Conditions

Creator:: Hsiao, Yu-Tin
Abstract:: There are clues that suggest human breast cancer cells use collagen fibers to migrate, and vinculin is a transmembrane protein associated with how cells attach to their environment. Therefore, immunostaining for the vinculin will shed some light in how human breast cancer cells are attaching to their environment. Immunostaining for...
Resource Type:: Honors College Thesis

Classification and Analysis of Nucleotide - Nucleotide Interactions in RNA

Creator:: Rouches, Mason
Abstract:: Base-pairing interaction are the fundamental blocks of an RNA structure. With increased ability to determine the structure of RNA molecules, an accurate and informative way of classifying these interactions would help to study RNA structure at many levels. Apart from the well-known complementary base pairs and wobble pairs, other interactions...
Resource Type:: Honors College Thesis

Lipids of the Stratum Corneum as Predictive Biomarkers for the Development of Atopic Dermatitis in a Pediatric Population

Creator:: Sato, William
Abstract:: Atopic Dermatitis (AD) is a widespread skin disorder, affecting some 20% of the world’s population. Though the precise molecular underpinnings are still being understood, changes in lipid composition within the epidermal stratum corneum (SC) layer have been shown to be closely linked with AD. Previous studies have identified several specific...
Resource Type:: Honors College Thesis

Ke Truyen Ma : Vietnamese Refugees Altering The Course of U.S. History, Kể Truyện Ma : Vietnamese Refugees Altering The Course of U.S. History

Creator:: Nguyen, Hai Yen T.
Abstract:: Since the 1960s, Vietnamese scholars have written autobiographical literature catered to the American public though they have not gotten as much recognition as soldier accounts and anti-war literature. These Vietnamese literatures shifted in scope and form with the succeeding waves of refugee resulted from the war in Việt Nam. As...
Resource Type:: Honors College Thesis

Investigation of KHV DNA Methylation during Productive and Latent Infection

Creator:: Lin, Lisa
Abstract:: Koi herpesvirus (KHV), is a highly pathogenic virus causing high mortality in common carp and koi, especially in fry. One of the unique features of herpesvirus infections is their ability to become latent following initial infection. During latent infection, only viral genome persists in the host and remains dormant in...
Resource Type:: Honors College Thesis

Assessing an Adult Zebrafish Model for In Vivo Delivery of Morpholino Oligomers

Creator:: Kim, Joseph Y.
Abstract:: Antisense morpholino oligomers are synthetic macromolecules can modify gene expression. While these compounds have great potential to treat a broad range of human diseases, they suffer from poor cellular delivery. Conjugating cell-penetrating peptides onto these morpholinos is one option of addressing delivery, however development remains slow due to the cost...
Resource Type:: Honors College Thesis

Adaptation to long-term osmotic stress in a domesticated Saccharomyces cerevisiae strain

Creator:: Holman, Douglas S.
Abstract:: Osmotic stress is a common challenge faced by organisms in environments with variable salinity or aridity. Understanding the evolutionary mechanisms underlying adaptation to osmotic stress may have wide applications, including management of populations experiencing climate change, or engineering industrial organisms involved in processes such as fermentation. While Saccharomyces cerevisiae is...
Resource Type:: Honors College Thesis

Characterizing the Interactome of Nitrotyrosine-Calmodulin using Genetic Code Expansion

Creator:: Kong, Garth L.
Abstract:: A specific tyrosine post-translational modification, called 3-nitro-tyrosine (nitroTyr), has been known to be present on an essential calcium signaling protein called calmodulin (CaM) during oxidative stress. While protein-bound 3-nitro-tyrosine has long been considered a biomarker of OS, it is also hypothesized to be a mechanism for protein signaling. However, purification...
Resource Type:: Honors College Thesis

Mutation of Polycomb Repressive Complex 2 (PRC2) kmt6 to Probe in vivo Function in Fusarium

Creator:: Josephson, Brian
Abstract:: Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase that initiates facultative heterochromatin formation by trimethylating histone H3 on lysine 27 (H3K27me3). Mutations within its three primary subunits, KMT6, EED, and SUZ12, result in inherited diseases and sporadic cancers. In the fungus Fusarium graminearum, deletion of the gene encoding the...
Resource Type:: Honors College Thesis

Oregon State Student Athlete Academic Performance Compared to that of the General Undergraduate Population

Creator:: Hannan, Joely
Abstract:: Academic performance of student athletes is an of interest topic in the current climate of rising university athletics expenses. This project academic population of Oregon State University student athletes with that of the general undergraduate population using grade point averages (GPA). Samples were compared using team, gender, college, and sport...
Resource Type:: Honors College Thesis

The role of sigma factors in production of cyanobacterial natural products: Escherichia coli as a heterologous expression host

Creator:: Wells, Kaitlyn N.
Abstract:: Cyanobacteria represent an underexploited source of bioactive natural products of interest to the pharmaceutical industry. Lack of development of these compounds as drug leads is due mainly to myriad practical problems with the producing strains including long doubling times, genetic intractability, and low compound yields. Previous attempts at heterologous expression...
Resource Type:: Honors College Thesis

Voluntary alcohol consumption in male rhesus macaques suppresses cancellous bone remodeling

Creator:: Kahler-Quesada, Arianna M.
Abstract:: Background: Chronic heavy alcohol consumption is a risk factor for bone fracture. Using a non-human primate model of voluntary alcohol self-administration, we have recently shown that alcohol consumption suppresses intracortical bone remodeling. The current study extends this investigation to asses the effect of alcohol consumption on cancellous bone mass, architecture,...
Resource Type:: Honors College Thesis

Pregnant in Puerto Rico : Maternal Perceptions of Zika- and Non-Zika Related Stress

Creator:: Nako, Eni
Abstract:: The purpose of this study was to examine pregnant Puerto Rican women’s perspectives on the Zika virus threat. Using data collected from open-ended, semi-structured interviews and observational field notes, we aimed to understand the degree to which Zika contributes to maternal stress. How concerned are pregnant women in Puerto Rico...
Resource Type:: Honors College Thesis

It's Not You, It's Me : An Inductive Exploration of Employee Accounts for Quitting

Creator:: Neaves, Emily
Abstract:: Key Words: Exit interview, voluntary turnover, dishonesty
Resource Type:: Honors College Thesis

Science performance of United States youth on international exams : A cross-cultural meta-synthesis

Creator:: Huss, Christiana H.
Abstract:: The purpose of this meta-synthesis was to investigate why students from the U.S. receive the scores they do on the international TIMSS and PISA science exams. This work sought to shed light on the perceived disparity between science performance of U.S. students and students from other countries. To do so,...
Resource Type:: Honors College Thesis

Comparative analysis of genes regulating HDL function and metabolism in macaques and humans

Creator:: Clarke, Jordyn M.
Abstract:: The role of the high density lipoprotein (HDL) molecule is currently an area of great interest within the scientific community. Previously, mouse and human studies have demonstrated an inverse association between HDL cholesterol (HDL-C) levels and cardiovascular disease. Recent clinical trials, which increased HDL-C, have failed to reduce the number...
Resource Type:: Honors College Thesis

An Accumulation of Senescent Cells May Contribute to Chronic Inflammation of the Mammalian Liver

Creator:: Sugiyama, Aaron
Abstract:: The aging process is a biological phenomenon in mammals that heavily contributes to the onset of chronic diseases. While there are many theories that attempt to explain the biological onset of aging, one emerging theory involves chronic inflammation. Chronic inflammation has been previously linked to several age-related diseases and is...
Resource Type:: Honors College Thesis

Effects of 6 months of voluntary alcohol self-administration on intracorticalbone remodeling in young adult male cynomolgus monkeys

Creator:: Kuah, Amida F.
Abstract:: Heavy chronic alcohol consumption has been linked to a myriad of detrimental skeletal effects. Many studies have been conducted to examine the effects of alcohol abuse upon cancellous bone. However, little is known about its effect upon cortical bone. The skeleton is comprised of approximately 80% cortical bone and thus...
Resource Type:: Honors College Thesis

Comparing 26S Proteasome Efficiency Between Long-Living and Short-Living Rodents

Creator:: Bradley, Lynda M.
Abstract:: Many people die yearly worldwide due to diseases associated with aging, and if the process of aging in humans was more understood, the health of these patients could be improved. While many biochemical actions are involved with the aging process, loss of proteostasis has been called one of the most...
Resource Type:: Honors College Thesis

Thermodynamic Design Principles for Double-Strand Displacement microRNA Biosensors

Creator:: Smith, Natasha M.
Abstract:: In recent years, microRNA’s (miRNA’s) have emerged as important in regulating gene expression. Fluctuations in their levels are associated with the up or down-regulation of tumor-suppressor genes and oncogenes. Thus, the ability to visualize changes in miRNA is an important step in understanding cancer emergence and development. The Burrows group...
Resource Type:: Honors College Thesis

Examining the Human Relevance of a New Mouse Model of ALS and Observations on the Incidence in Human Populations

Creator:: Winkenbach, Lindsay
Abstract:: Amyotrophic Lateral Sclerosis (ALS) is a relatively rare neurodegenerative disorder that is fatal 2-4 years after the onset of the disease. Population studies are being done in order to help reveal candidates for further studies of disease etiology, disease progression, as well as to further understand racial and ethnic variations....
Resource Type:: Honors College Thesis

Site-Specific Modification of Glucose Proteins Enabling Precise Surface Orientation For Glucose Sensors

Creator:: Wolfenden, Nurhayati
Abstract:: An ideal labeling reaction between protein and surface should generate a protein-patterned surface with control over the orientation of the desired protein. Controlling orientation would generate a homogeneous, un-fouled protein surface and allow for maximum efficiency in regards to the activity, reactivity, and stability of the protein. In this research...
Resource Type:: Honors College Thesis

Analysis of particulate organic matter distribution along surface waters of the California Current

Creator:: Welch, Kylie
Abstract:: Water samples along the Washington, Oregon and California coastline were collected using high resolution sampling and analyzed to determine particulate organic carbon and nitrogen concentrations. Over 28 days during August 2011, nearly 1500 samples were collected aboard the R/V Wecoma (W1108C) using a semi-automated filtration system. Additional subsurface samples were...
Resource Type:: Honors College Thesis

Investigation of autophagy-assisted cell death in response to the cancer cell toxin coibamide A

Creator:: Tan, Michelle
Abstract:: Autophagy, a homeostatic degradation pathway, has a role in promoting cell survival under stress conditions, but can also promote cell death under conditions of sustained stress. This project investigates the cytotoxic potential of coibamide A and other natural products in autophagy-deficient and wild-type mouse embryonic fibroblasts (MEFs). Wild-type MEFs were...
Resource Type:: Honors College Thesis

Generation of multiple geneauxotrophs for use as selectable markers in Fusarium graminearum

Creator:: Fargo, Corinne Marie
Abstract:: Auxotrophic strains of the fungus Fusarium graminearum were generated in order to increase the number of functional selectable markers and improve the utility of the model organism. Single metabolic genes, the sequences encoding for enzymes required for the production of specific essential metabolites, were deleted in F. graminearum, and then...
Resource Type:: Honors College Thesis

Isolation, Characterization, and Antibiotic Activity of Fungal Metabolites from an Algal Endophyte

Creator:: Stoumbos, Demetri
Abstract:: Pseudomonas aeruginosa is a gram-negative nosocomial pathogenic bacterium known for its resilience against antibiotics. The bacterium infects over 50,000 patients each year in the United States, with 13% of reported cases involving multi-drug-resistant strains of Pseudomonas. This research discovered several fungal natural products with promising activity against Pseudomonas aeruginosa. The...
Resource Type:: Honors College Thesis

Transportation Design To Facilitate Urban Growth In Pakistan: Structural Reform For Economic Mobilization

Creator:: Khan, Lubna
Abstract:: There is a rapid shift towards urbanization all over the world. In developing countries like Pakistan, the urbanization process is under-planned leading to the haphazard growth of existing cities without enough resources to fit the needs of the residents. Cities in Pakistan lack good transportation systems, which creates inaccessibility to...
Resource Type:: Honors College Thesis

Adding value to renewable biodiesel production from the oleaginous yeast Lipomyces starkeyi

Creator:: Brosy, Jack R.
Abstract:: Global warming and on-going depletion of fossil fuels have stimulated research to develop renewable sources of energy. Current renewable energy use comprises only 10% of the energy consumed in the US and is focused mostly on generating electricity. The majority of the energy consumed by the US transportation sector is...
Resource Type:: Honors College Thesis

Investigating compounds to target glioblastoma progression

Creator:: Cade, Emily Elizabeth
Abstract:: Glioblastoma multiforme is a devastating primary brain tumor with a median five year survival rate of less than 5%. It is a cancer that is resistant to current cancer treatments, such as surgery and chemotherapy, as well as one that is prone to recurrence after surgical removal. This highlights the...
Resource Type:: Honors College Thesis

A quantitative analysis of three-dimensional contact guidance by breast cancer cells

Creator:: Krnacik, Emma A.
Abstract:: Exploring and quantifying the parameters regarding contact guidance may provide valuable insight to the precise mechanisms controlling cell movement, especially in a three-dimensional environment. The objective of this project was to quantify the relationship between MDA-MB-231 cell morphogenesis and the geometry of the cell’s local microenvironment, which was modeled by...
Resource Type:: Honors College Thesis

Exposure to the Mycotoxin Zearalenone Impairs Embryonic Development in Zebrafish

Creator:: Sidebotham, Nicole A.
Abstract:: A study was conducted to evaluate the developmental toxicity of three commonly detected mycotoxins in food (deoxynivalenol, patulin, and zearalenone) using the zebrafish (Danio rerio) model. Mycotoxin exposures were carried out at five concentrations (0.0064, 0.064, 0.64, 6.4, and 64 μM). Morphological and photomotor screenings were conducted at 24 hours...
Resource Type:: Honors College Thesis

Characterization of Fer1L6 in the mouse C2C12 cell line

Creator:: Huegel, Jacob T.
Abstract:: Fer1L6 is an uncharacterized member of the ferlin family of proteins, a group of large, calcium sensitive proteins with emerging roles in vesicle trafficking and various disease states. The presence of Fer1L6 has been identified within the C2C12 cell line of mouse skeletal muscle. To determine the protein’s subcellular location...
Resource Type:: Honors College Thesis

Exploring the neuroprotective mechanism of poly-ICLC preconditioning against oxygenglucose deprivation in the in vitro blood-brain barrier model

Creator:: Turina, Claire B.
Abstract:: The preconditioning agent poly-ICLC has recently been shown to protect against cerebral injury in the mouse model, when administered systemically prior to ischemic insult. However, the mechanism by which poly-ICLC provides neuroprotection is currently unknown, but it has been shown to protect against ischemia-induced bloodbrain barrier (BBB) disruption. Inflammation contributes...
Resource Type:: Honors College Thesis

Identification of potential new biomarkers of oxygenated polycyclic aromatic hydrocarbon (OPAH) exposures in zebrafish.

Creator:: Swanson, Annika J.
Abstract:: Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are a class of environmentally prevalent compounds with little known information on their effect in vivo. In a recent study conducted using zebrafish as a model, 38 OPAHs were screened for toxicity. This investigation focuses on two of these OPAHs, 7,12-B[a]AQ and BEZO. Both 7,12-B[a]AQ...
Resource Type:: Honors College Thesis

Calpain 2 Cleavage of Akt in Glioblastoma Multiforme

Creator:: Zhang, Justin
Abstract:: Glioblastoma is a malignant brain tumor that has extremely poor prognoses with a 5 year survival rate of less than 5%. The low survival rates of glioblastoma patients is attributed to glioblastoma cells being extremely resistant to radiotherapy and chemotherapy as well as being very invasive. We previously identified calpain...
Resource Type:: Honors College Thesis

Quantification of Lipoic Acid InducedChanges in Nrf2-Mediated Stress Response

Creator:: Hobbs, Helen T.
Abstract:: As organisms age they lose the ability to respond to both exogenous and endogenous stresses, therefore placing them at a greater risk for the development of many diseases. The transcription factor Nrf2 is responsible for the induction of many oxidative stress response genes and therefore 3proteins. Additionally, Nrf2-mediated stress response...
Resource Type:: Honors College Thesis

The Creation of a Bilingual Children’s Book to Promote Mental Health Services among U.S. Latin@s

Creator:: Tolmach, Oresta S.
Abstract:: Although U.S. Latin@s are more affected by major depressive disorder than non-Latin@ whites, they are less likely to utilize mental health services. The purpose of this project is to create a children’s book that promotes the utilization of mental health services among U.S. Latin@s with major depressive disorder. This book...
Resource Type:: Honors College Thesis

Interaction of the human Voltage-Dependent Anion Channel 1 protein (VDAC-1) with Mycobacterium avium and its role in bacterial survival within phagocytic cells

Creator:: Pham, Tuan
Abstract:: M. avium is an opportunistic pathogen that primarily infects macrophages. In order to survive within the macrophage, M. avium secretes proteins into the host cell cytoplasm to inhibit specific functions such as phagosome acidification, altering pathways as well as initiating apoptosis. However, little is known about how those secreted proteins...
Resource Type:: Honors College Thesis

Ernesto "Che" Guevara : An Analysis of What the Argentine Revolutionary Truly Personified and the Accuracy of Representation in American Culture

Creator:: Judd, Grace I.
Abstract:: It is no doubt that the face of Ernesto "Che" Guevara is recognized globally as it appears on currency, merchandise, at protest marches, and in art. However, there is little agreement on what this handsome face represents or what the Argentine revolutionary fought for. Some view Guevara as a humanitarian...
Resource Type:: Honors College Thesis

Permeability of Various Thyroid Hormone Derivatives and Discovery of a Novel Metabolite

Creator:: Kirkemo, Lisa
Abstract:: In this investigation, six different endogenous thyroid hormone derivatives—T₄, T₃, TA₄, TA₃, T₁-Amine, and N-Acetylated T₁-Amine—were tested to gain insight into their permeability coefficients and efflux ratios across a monolayer of Madin-Darby Canine Kidney (MDCK II) cells. The results indicate that T₃ and T₄ were unable to traverse the membrane...
Resource Type:: Honors College Thesis

Dissecting DNA Damage Responses in Arabidopsis: A High-Throughput Sequencing Approach

Creator:: Brar, Anantnoor
Abstract:: A unique, permanent root-growth arrest phenotype was observed in UV-B irradiated Arabidopsis thaliana roots lacking the DNA damage response kinase ATR. Segregation analysis suggests the dependence of this phenotype on another, unidentified gene, termed ursu. High-throughput sequencing technologies were used to map and identify the causal ursu mutation. Illumina HiSeq...
Resource Type:: Honors College Thesis

Exploring Chromodomain Genes in the Fungus Fusarium graminearum Through Targeted Genetic Manipulation

Creator:: Peters, Alec
Abstract:: DNA segments in the fungus Fusarium graminearum were identified as possible genes encoding for chromodomain proteins (CDPs), and targeted for genetic manipulation. Targeted single-gene deletion strains, as wells as GFP-S tag fusion strains, were generated from wildtype F. graminearum protoplasts, and verified strains were screened for phenotypic differences, such as...
Resource Type:: Honors College Thesis

Peptide Non-planarity Regained

Creator:: Biel, Justin T.
Abstract:: The planar peptide model has guided our understanding and interpretation of protein crystal structures since its origin in the 1950s. It is well understood that deviations from this model occur, but the majority of peptides are planar, as measured by the standard omega torsion angle. Here, we report the first...
Resource Type:: Honors College Thesis

Mutations of CenH3 Domains and their Effect on Chromocenter Localization and Meiosis in Neurospora crassa

Creator:: Ferrer, Sarah Theresa
Abstract:: In recent years, non-coding DNA has received much attention within the scientific community. This attention has not only illuminated the mystery behind functionally important regions like the centromere, but has also brought to light additional important questions regarding centromere mechanisms, inheritance, and cellular recognition by the kinetochore, a protein complex...
Resource Type:: Honors College Thesis

Dissecting DNA Damage Responses in Arabidopsis: A High-Throughput Sequencing Approach

Creator:: Brar, Anantnoor K., Wilcox, Buck W. L., Curtis, Marc, and Hays, John B.
Abstract:: Cells are constantly bombarded with mutagens, both endogenous and exogenous in origin. Endogenous sources of mutation include reactive oxygen species formed during aerobic respiration, replication errors by DNA polymerase, and spontaneous deamination and depurination (Jackson 2009). Exogenous sources of mutation include UV and ionizing radiation, aflatoxins, and polycyclic aromatic hydrocarbons...
Resource Type:: Honors College Thesis

Identification of the Polycomb Repressive Complex 2 in Fungi

Creator:: Pham, Phuong and Freitag, Michael
Abstract:: The process of expressing a gene involves not just binding of proteins and enzymes to DNA to produce first RNA and eventually proteins, but rather association of these transcription factors with chromatin and structural proteins called histones. When histone H3 is trimethylated at lysine 27 to produce H3K27me3, gene silencing...
Resource Type:: Honors College Thesis

Identification of a compound series by high throughput screening capable of reversing the antiviral effect of Ribavirin in tissue culture

Creator:: Gallion, Jonathan
Abstract:: A compound series capable of reversing the antiviral effect of Ribavirin (RBV) against H1N1 was identified from a high throughput screen designed to discover compounds capable of increasing the fidelity of the RNA-dependent RNA polymerase (RDRP) n ribovirus quasispecies. Two lead compounds, RIC-1 (EC50 of 78.4 nM) and RIC-2 (EC50...
Resource Type:: Honors College Thesis

Nongenomic Actions of Steroid Hormones in the Ovine Endometrium

Creator:: Ireton, Kyle E.
Abstract:: The steroid hormone estrogen plays a crucial role in regulating certain mammalian tissues, especially female reproductive systems. Estrogen effects physiological changes in the cell by altering transcription activity for certain target genes, as a consequence of interactions between estradiol-17β (E2) and its nuclear receptor (nER). This mechanism of cellular control...
Resource Type:: Honors College Thesis

Gender-Dependent Mechanisms of Alpha-Tocopherol Protection from Benzo[a]pyrene Exposure in Rats

Creator:: Crimp, Caitlin A.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (B[a]P), are environmental pollutants linked to increased disease susceptibilities. Alpha-Tocopherol (αT) supplementation decreases B[a]P-DNA adducts in smokers, particularly women; but the mechanism is unknown. To test the hypothesis that αT protection from B[a]P exposure is gender-dependent, male and female rats received 7 daily subcutaneous...
Resource Type:: Honors College Thesis

Involvement of PP6 in Dephosphorylation of Bcl11b, a Tumor Suppressor Transcription Factor

Creator:: Parker, Chelsea R.
Abstract:: The purpose of this honors thesis research project is to investigate the molecular causes of childhood and infant T-cell acute lymphoblastic leukemias. T-cells are the work horses of the immune system, and like any organ, must develop properly to be fully functional. Improper development of thymocytes into T-cells can lead...
Resource Type:: Honors College Thesis

The Soul of Global Medicine: Tales from the International Bedside

Creator:: Derrah, Ryan
Abstract:: In his work, The Soul of Medicine: Tales from the Bedside, Dr. Sherwin Nuland utilized narratives from his colleagues detailing their encounters with their most remarkable patients in order to characterize what he refers to as “the soul of medicine”. However, the stories contributed focused on the practice of medicine...
Resource Type:: Honors College Thesis

The Development of Computational Methods for Studying Plant-Pathogen Interactions

Creator:: Pankow, Rebecca C.
Abstract:: Modern technology has enabled the advancement of biological research through the use of powerful machines and computers as well as innovative computer programs. Advances in sequencing technology and software enable us to make de novo assemblies of organism genomes, and the development of specialized computer programs can automate routine but...
Resource Type:: Honors College Thesis

The Role of Arabidopsis RNA-Dependent RNA Polymerase Genes 3, 4 and 5 in Antiviral Defense

Creator:: Lowery, Nicholas C.
Abstract:: RNA silencing plays a critical role in plant defense against viral infection. Plants use virusderived small interfering RNA to target and silence invading viruses. The antiviral silencing pathway can be broken down into three conceptual stages: initiation, amplification, and systemic movement. The molecular mechanisms of silencing initiation are not well...
Resource Type:: Honors College Thesis

UVB Radiation Affects the Quality of the Female Sexual Attractiveness Pheromone of the Red-Sided Garter Snake

Creator:: Vigeland, Anna E.
Abstract:: In this study, pheromone and skin lipid samples collected from red-sided garter snakes (Thamnophis sirtalis parietalis) were exposed directly to either full-spectrum light or full-spectrum plus UVB light. In addition, female and male snakes were exposed to daily doses of either full-spectrum or full-spectrum and UVB light, after which the...
Resource Type:: Honors College Thesis

Activation of Co-stimulatory Molecule OX40 Increases Memory T-cell Function and Cytokine Production in Uveitis

Creator:: Hall, Mark
Abstract:: Uveitis is a serious ophthalmological disorder characterized by intraocular infiltration of inflammatory cells. In most cases, uveitis is derived from the adaptive immune response. More specifically, CD4+ T lymphocytes play an important role in the pathogenesis of uveitis by recognizing uveitogenic antigen and orchestrating the immune response. While it is...
Resource Type:: Honors College Thesis

Investigations into the Mechanism of Action of Dengue Virus Inhibitor Compounds

Creator:: Schneider, Christine A.
Abstract:: Several compounds have been recently identified which are effective against dengue virus, a tropical arbovirus highly prevalent in southeast Asia and central America. Initial intrinsic fluorescence characterization of the mechanism of action of compound B reveals binding affinity to the dengue capsid protein. A molecular beacon unwinding assay and malachite...
Resource Type:: Honors College Thesis

Assessment of academic advising models in the OSU College of Science based on student and advisor feedback

Creator:: Aljets, Alexandria Dukes
Abstract:: This study sought to explore the differences between the varied academic advising models in the College of Science at Oregon State University through the feedback of its undergraduate students and advisors. Using parallel surveys of students and their academic advisors, it found that the decentralized and centralized models each had...
Resource Type:: Honors College Thesis

Living Gluten-Free: An Analysis of Illness and Coping Narratives

Creator:: Dougher, Carly E.
Abstract:: Gluten intolerance is a condition that affects a significant portion of the world’s population. While awareness about the condition has recently increased, the condition remains poorly understood and therefore commonly mis- and underdiagnosed. In this paper, I examine the challenges in obtaining a gluten intolerant diagnosis and attempt to capture...
Resource Type:: Honors College Thesis

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