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Filtering by: Creator Brown, Sean P. Remove constraint Creator: Brown, Sean P. Decade 2010-2019 Remove constraint Decade: 2010-2019 Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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  • Innovative Bioanalytical Tools & Methods for Combinatorial Non-Coding RNA Analysis

    Creator:
    Zhang, Lulu
    Abstract:
    Recently researchers have discovered that groups of small non-coding RNAs (ncRNAs) play regulatory roles in gene expression and participate in various biological processes. For example, pathogenesis of many diseases, cell cycle regulation, and signaling pathways. Intracellular and live cell imaging of small ncRNA groups will reveal their relative expression levels...
    Resource Type:
    Dissertation
    Full Text:
    Sean M. Burrows Recently researchers have discovered that groups of small non-coding RNAs

  • Displacement-based fluorescent microRNA biosensors : design principles and analytical metrics

    Creator:
    Larkey, Nicholas E.
    Abstract:
    One post-transcriptional mechanism that regulates the progression of cancer and other diseases involves small 22-23 nucleotide sequences called microRNA (miR). Early detection of small changes in concentration of these biomarkers holds potential to diagnose diseases at their earliest stages. Use of current nucleic-acid based biosensors, like molecular beacons, for in...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: ______________________________________________________ Sean M. Burrows

  • Pseudoloma neurophilia in the Zebrafish (Danio rerio) : Consequences of Infection on Neurobehavioral and Biomedical Research using a Burgeoning Model Organism

    Creator:
    Spagnoli, Sean
    Abstract:
    Since its inception as a laboratory animal in the early 1970s, the zebrafish has proven itself a rising star in the world of comparative biomedical sciences due to its short generation time, ease of care, external fertilization, and transparent larvae. In a very few decades, the zebrafish has been utilized...
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE DISSERTATION OF Sean Spagnoli for the degree of Doctor of Philosophy in Comparative

  • CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

    Creator:
    Almlie, C. Kyle
    Abstract:
    Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
    Resource Type:
    Dissertation
    Full Text:
    approved: ______________________________________________________ Sean M. Burrows Fluorescence has

  • Gold Nanostars: Spectroscopic and Physical Properties

    Creator:
    Zhou, Lixia
    Abstract:
    Tethering fluorophores on metal nanoparticles for metal enhanced fluorescence (MEF) has attracted a lot of attention from scientists interested in fluorescence based approaches. MEF has many benefits in fluorescence related techniques, because the analytical signal increases and enables potentially lower detection limits or better sensitivity. Many types of nanoparticles have...
    Resource Type:
    Dissertation
    Full Text:
    Sean M. Burrows Tethering fluorophores on metal nanoparticles for metal enhanced

  • Outdoor Behavioral Healthcare Outcomes for Young Adults

    Creator:
    Roberts, Sean D.
    Abstract:
    Those experiencing significant psychosocial problems in adolescence and young adulthood are at higher risk for psychological disorder (Pottick, Bilder, Vander Stoep, Warner, & Alvarez, 2008). Compared to peers, these individuals struggle to complete school, fit with social roles, and acquire occupational skills necessary for adulthood (Pottick et al., 2008). Providing...
    Resource Type:
    Dissertation
    Full Text:
    OF THE DISSERTATION OF Sean D. Roberts for the degree of Doctor of Philosophy in Counseling

  • Structure-property relationships of layered oxypnictides

    Creator:
    Muir, Sean W.
    Abstract:
    Investigating the structure-property relationships of solid state materials can help improve many of the materials we use each day in life. It can also lead to the discovery of materials with interesting and unforeseen properties. In this work the structure property relationships of newly discovered layered oxypnictide phases are presented...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Sean W. Muir for the

  • The effects of community composition, landscape structure, and climate on host-pathogen interactions

    Creator:
    Moore, Sean M.
    Abstract:
    Like other species interactions in ecological systems, host-pathogen interactions are influenced by environmental factors, landscape characteristics and the broader community context. My thesis explores the potential influences of food-web interactions (Chapter 2), climate change (Chapter 3), landscape structure and host movement patterns (Chapter 4), and the combined influences of local...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Sean M. Moore for the

  • Machine learning methods for public policy : simulation, optimization, and visualization

    Creator:
    McGregor, Sean
    Abstract:
    Society faces many complex management problems, particularly in the area of shared public resources such as ecosystems. Existing decision making processes are often guided by personal experience and political ideology rather than state-of-the-art scientific understanding. This dissertation envisions a future in which multiple stakeholders are provided with computational tools for...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Sean McGregor for the

  • Conceptual Representations within the Social and Material Contexts of an Engineering Workplace and Academic Environments

    Creator:
    Barner, Matthew S.
    Abstract:
    Situated cognition theory emphasizes the role that social and material contexts have on learning and knowledge application. Several studies of engineering workplace environments have noted differences between the social and material contexts of the workplace and those of undergraduate engineering education. No existing research has studied the social and material...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Shane A. Brown Situated cognition theory emphasizes the role that social and material