Small chemicals like drugs tend to bind to proteins via noncovalent bonds, e.g. hydrogen bonds, salt bridges or electrostatic interactions. Some chemicals interact with other molecules than the actual target ligand, representing so-called ‘off-target' activities of drugs. Such interactions are a main cause of adverse side effects to drugs and...
What affects the oceans affects terra firma. Ocean Solutions, Earth Solutions gathers the insights of more than 50 ocean and coastal science researchers exploring ocean components and their relationships, patterns, and trends over time and space. The book's 16 chapters feature geographic information system (GIS) best practices and include additional...
A new matrix operator framework is developed to analyze results from climate modeling studies that employ numerical water tracers (WTs), which track the movement of water in the aerial hydrological cycle from evaporation to precipitation. Model WT output is related to the fundamental equation of hydrology, and the moisture flux...