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Filtering by: Creator Finkenbiner, Catherine E. Decade 2010-2019 License Attribution-NonCommercial-NoDerivs 3.0 United States

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C‐MYC depletion

Creator:

Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Leonova, Katerina I., Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Berman, Albert E., Flanagan, Sheryl, Shewach, Donna S., Zeitouni, Nathalie C., Gudkov, Andrei V., Mathews, Christopher K., and Nikiforov, Mikhail A.

Abstract:

The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depleted melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and ribonucleotide...

Resource Type:

Article

Full Text:

J. Wheeler3, Katerina I. Leonova1, Joseph A. Wawrzyniak1, Anna Bianchi‐Smiraglia1, Albert E
2009/2010 Annual Report

Creator:

Hatfield Marine Science Center

Abstract:

Report year ends June 30

Resource Type:

Other

Full Text:

workshop for staff at the JRC. His other teaching activity was teaching the e-campus version of his OSU