Search Constraints

Start Over
Filtering by: Creator Lange, Sandra L. Remove constraint Creator: Lange, Sandra L. Decade 2010-2019 Remove constraint Decade: 2010-2019 Rights Statement In Copyright Remove constraint Rights Statement: In Copyright

Search Results

  • A robust Mycobacterium smegmatis Assay for the Discovery of Anti-tubercular Metabolites from Soil Bacteria

    Creator:
    Chen, Kathryn P
    Abstract:
    Tuberculosis (TB) is a pressing global health issue with approximately one third of the world’s population infected by this bacterium. As one of the most dangerous infectious diseases, it has killed approximately 1.7 million people of all ages around the world per year (World Health Organization, 2016). Currently, several drugs...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Sandra Loesgen Tuberculosis (TB) is a pressing global health issue with

  • Insights into Cytostatic and Cytotoxic Properties of the Natural Product Mensacarcin

    Creator:
    Kaweesa, Elizabeth Namagoba
    Abstract:
    Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: ______________________________________________________ Sandra Loesgen Mensacarcin is a

  • Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

    Creator:
    Zhu, Chenxi
    Abstract:
    Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
    Resource Type:
    Dissertation
    Full Text:
    approved: _____________________________________________________ Sandra Loesgen Exploring bioactive

  • Magmatic processes beneath mid-ocean ridges : insights from mineral and glass chemistry in plagioclase ultraphyric basalts

    Creator:
    Lange, Amy E.
    Abstract:
    Prior to eruption at mid-ocean ridges, melts must travel through >6 km of crust from their origin in the mantle. The final composition of the melts is dependent on both the melting conditions and magmatic processes within the crust. While mid-ocean ridge basalt (MORB) glasses are commonly used to infer...
    Resource Type:
    Dissertation
    Full Text:
    Amy E. Lange Roger L. Nielsen Frank J. Tepley III Adam J.R. Kent This manuscript is

  • Native Bee and Spider Community Responses to Grassland Restoration and Wildfire

    Creator:
    Smith DiCarlo, Lauren A.
    Abstract:
    Up to 99.9% of native North American grasslands have been degraded since European settlement, primarily due to agricultural conversion. Today, grasslands are a top priority for restoration as they provide essential habitat for many rare and endangered species; however, the majority of studies in grasslands have focused on vegetation or...
    Resource Type:
    Dissertation
    Full Text:
    approved: ______________________________________________________ Sandra J. DeBano Up to 99.9% of

  • Psychological Elements of Trauma and Grief among Young Banso Widows in Cameroon

    Creator:
    Lange, Ruth Kinyuy
    Abstract:
    Because of disease, industrialization, and regional conflicts, young widowhood is an expanding phenomenon in many parts of the world. Young widows face many challenges that can lead to mental health problems. The young widows have to make adjustments to fit their new roles as bread winners of the families, having...
    Resource Type:
    Dissertation
    Full Text:
    Ruth Kinyuy Lange for the degree of Doctor of Philosophy in Counseling presented on December 9, 2016

  • Numerical response of concrete-lined tunnels crossing active faults

    Creator:
    Lange, Stephanie
    Abstract:
    A challenge for municipal authorities of growing urban areas is to provide larger and faster transportation and utility networks that are safe and resilient to significant disruptions after an earthquake event and other disasters. Urban regions, like the San Francisco Bay or the Los Angeles area, are situated in seismically...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Stephanie Lange for the

  • Bioactivity Screening and Gene Activation Strategies in Fungi

    Creator:
    Coddington, Nathan C.
    Abstract:
    Natural products from plants, bacteria, and fungi play an important role in society. Over the last 35 years, natural products and their derivatives have inspired over 60% of all FDA approved small-molecule drugs, and are among the top prescribed therapeutics.1-2 Fleming’s discovery of the fungal antibiotic penicillin started the “Golden...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Abstract approved: ______________________________________________________________ Sandra Loesgen

  • Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

    Creator:
    Adpressa, Donovon A.
    Abstract:
    Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
    Resource Type:
    Dissertation
    Full Text:
    : _____________________________________________________________________ Sandra Loesgen Fungi have long been a prolific source of clinically approved drugs. The

  • A Dive into the Pacific Fish Microbiome: Exploration of Antibiotics from a Unique Ecosystem

    Creator:
    Austin, Molly C.
    Abstract:
    With the rise of resistant bacterial pathogens, currently prescribed antibiotics are rendered useless. In recent years, marine natural products (MNPs) have emerged as novel sources for drug leads. The ocean is a complex environment where marine animals cohabitate with many, and sometimes harmful microorganisms and viruses, but resist infections. Developed...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Sandra Loesgen With the rise of resistant bacterial pathogens, currently prescribed