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Filtering by: Committee Member O'Neill, J. Philip Remove constraint Committee Member: O'Neill, J. Philip Decade 2010-2019 Remove constraint Decade: 2010-2019 Rights Statement In Copyright Remove constraint Rights Statement: In Copyright

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  • Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

    Creator:
    Nazari, Mohamad
    Abstract:
    Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...
    Resource Type:
    Dissertation
    Full Text:
    –1282. 39. Shair, M.; Yoon, T.; Mosny, K.; Chou, T.; Danishefsky, S. J. Am. Chem. Soc. 1996, 118

  • Evaluation of different monitoring strategies for public health protection : harmful algal bloom surveillance at Devils Lake, Lincoln City, OR

    Creator:
    Hitchko, Kara L.
    Abstract:
    Cyanobacteria are photosynthetic bacteria capable of producing toxins, including complex cyclic peptides called microcystins. Hazardous cyanobacterial blooms are an emerging public health concern and are monitored throughout Oregon in various recreational and drinking water bodies. Oregon has been proactive and responsive to the problems associated with toxic cyanobacterial blooms, but...
    Resource Type:
    Masters Thesis
    Full Text:
    :;!O:!Q346!>4/43>435/A!/?/AB>3>2!&6/?7! B8E!48!L/??B!a/?39?:8>!/?;!">>3>4/?4

  • Development of Methods for Stereoselective Carbon-Carbon Bond Formation

    Creator:
    Wu, Zhenhua
    Abstract:
    Three distinct methods to achieve the stereoselective synthesis of carbon-carbon bonds were investigated, encompassing: (i) the formation of axially chiral biaryl molecules by enantioselective Suzuki cross-coupling, (ii) the synthesis of α-phenylalkylboronic esters by enantioselective chain extension, and (iii) the stereospecific synthesis of alkenes by eliminative cross-coupling of enantioenriched sp³-hybridized carbenoids....
    Resource Type:
    Dissertation
    Full Text:
    boronates with a combination of O- (-lithiobenzyl)-N,N-diisopropylcarbamate and ligand 3,3-bis[(4S)-4,5

  • Biosynthesis and modification of the antibiotic enduracidin

    Creator:
    Goebel, Neal C.
    Abstract:
    The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
    Resource Type:
    Dissertation
    Full Text:
    N S H N H O OH O O N N NH2 NH2 S H2N O O NH2 S H2N O O Figure 1.1 A) Structure of

  • The Effects of Temperature on Electrical Resistivity Measurements of Concrete

    Creator:
    Coyle, Alex T.
    Abstract:
    Measuring resistivity as a method to calculate formation factor is becoming a popular way to evaluate transport properties of concrete. Resistivity measurements are dependent on multiple factors including the resistivity of the pore solution, leaching effects, the degree of saturation of the specimen, the age of the specimen (degree of...
    Resource Type:
    Masters Thesis
    Full Text:
    literature reveals that Ea-cond values vary from 9 to 39 kJ/mol, for pore solutions, pastes, mortars and

  • Incorporating Uncertainty in Truckload Relay Network Design

    Creator:
    Mokhtari, Zahra
    Abstract:
    In a relay network for full truckload (TL) transportation, facilities known as relay points (RPs) serve as exchange points where truck drivers can exchange trailers. This would help carriers to assign more regular tours to drivers when compared to the excessively long tours that exist in the traditional Point-to-Point (PtP)...
    Resource Type:
    Dissertation
    Full Text:
    where a load is transported from node i to node j using three RPs. Figure 1: Example of a