Index Catalog // ScholarsArchive@OSU

Testing Continuity between Versions 5.3.9 and 6.3.1 of Plaque Simulator for Planning Eye Plaque Brachytherapy Cases

Creator:: Polsdofer, Elizabeth M.
Abstract:: The purpose of this study is to examine the challenges of accepting and commissioning a new treatment planning system for eye plaque brachytherapy. Currently Oregon Health and Science University (OHSU) utilizes v5.3.9 of the Plaque Simulator software to plan all of its eye plaque brachytherapy cases. However, v5.3.9 is no...
Resource Type:: Masters Thesis

Multi-scale Investigation of Bidirectional Feedback Mechanism Between Breast Cancer Cells and Extracellular Matrix

Creator:: Kim, Jihan
Abstract:: Cell migration is fundamental for physiological processes such as immune re-sponses, wound healing and development. It is also a critical characteristic of metastatic cancer cells. An extensive amount of studies have focused on 2D sub-strates in order to understand the mechanism of cancer metastasis. However, much less is known about...
Resource Type:: Dissertation
Full Text:: suggestions: David McIntyre, Oksana Ostroverkhova, Weihong Qiu, and Collin Johnson, as well as my

Electrochemical Micro-sensors for Probing Bacterial Metabolic Behavior with Scanning Electrochemical Microscopy

Creator:: Jayathilake, Nadeeshani M.
Abstract:: Dental plaque is one of the well-characterized biofilms in the human body. Oral bacterial species play vital roles in maintaining healthy bacterial homeostasis as well as causing oral infections. Many of the oral diseases are caused by opportunistic pathogens, and therefore, the bacterial metabolic activities become important in dictating their...
Resource Type:: Dissertation
Full Text:: . Remcho, Dr. David Ji, Dr. Sean Burrows, Dr. Wei Kong and Dr. Weihong Qiu for your valuable advice and

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

Creator:: Blizzard, Robert J.
Abstract:: The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...
Resource Type:: Dissertation

Single-molecule in vitro Characterization of Otoferlin

Creator:: Hams, Nicole J.
Abstract:: Congenital hearing loss is a common disorder and over 60 mutations in the sensory hair cell protein, otoferlin, have been linked to pre-lingual deafness. Although otoferlin is essential for hearing, the large size and low solubility of the protein have limited approaches to study its function on a molecular-level. To...
Resource Type:: Dissertation
Full Text:: members, Dr. Elisar Barbar, Dr. Kate Schilke, Dr. Victor Hsu and Dr. Weihong Qiu, as well as Dr. Ryan

Nonlinear behavior of thermal and ion transport at the nanoscale

Creator:: Sahu, Subin
Abstract:: Functional control at the nanoscale forms the foundation of biological systems. These work at the cellular level by manipulating ions and molecules. Nanoscale devices that give functional control at this scale are also becoming an important component in diverse fields such as electronics, medicine, engineering, and manufacturing. Moreover, scientific advances...
Resource Type:: Dissertation
Full Text:: , Guenter Schneider, Weihong Qiu and P. Alex Greaney for their instructions. I also want to thank the

Exploring Protein Structure: Seeing the Forest and the Trees

Creator:: Brereton, Andrew E.
Abstract:: Life on Earth intimately depends on the function of countless proteins. For the majority of studied proteins, function absolutely depends on conformation (i.e. 3-dimensional shape in solution). The exact nature of how a protein goes from an unfolded linear polypeptide chain to an organized folded molecule is still not known,...
Resource Type:: Dissertation

CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

Creator:: Almlie, C. Kyle
Abstract:: Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
Resource Type:: Dissertation

Mechanics of three-dimensional microenvironments of cells

Creator:: Jones, Christopher
Abstract:: The structure and mechanics of tissues affect many important cellular functions such as migration, differentiation, and growth. Mechanical interactions between cells and the extracellular matrix (ECM), as well as ECM-mediated mechanical communication between cells, plays a part in coordinating collective cellular dy- namics during critical processes such as morphogenesis, tissue...
Resource Type:: Dissertation

Information Processing in Multicellular Networks

Creator:: Potter, Garrett D.
Abstract:: The ability for individual cells and multicellular networks to process information contained in perceived stimuli is of vital importance to their proper functioning and ultimately their cellular fate. The primary mechanism employed by cells to this end is the use of biochemical signaling in which a series of molecular events...
Resource Type:: Dissertation

Refractory Amorphous Metal Thin Films

Creator:: Olsen, Kristopher R.
Abstract:: Amorphous metal thin films lack the grain boundaries and dislocations present in crystalline metal films. As a result, amorphous metal films can be more mechanically robust, atomically smooth, and more resistant to chemical attack than crystalline metals. However, amorphous metals are meta-stable and subject to crystallization upon heating, thus limiting...
Resource Type:: Dissertation

Initial in vitro and in vivo Characterization of the Membrane Trafficking Protein Fer1L6

Creator:: Wolk, Chelsea
Abstract:: A fundamental difference between prokaryotic and eukaryotic cells is the presence of membrane bound organelles in eukaryotes. The dynamics of membrane trafficking within the cell are responsible for everything from intercellular communication and cell homeostasis, to mitosis, cell migration, and differentiation. These processes require exocytosis and compensatory endocytosis, often working...
Resource Type:: Dissertation
Full Text:: . Weihong Qiu, and Dr. David Hendrix. Also, this type of graduate work would not be possible without

Protein Disorder in the Evolution of Dynein Regulation

Creator:: Jie, Jing
Abstract:: Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...
Resource Type:: Dissertation
Full Text:: committee members, past and present, Dr. Andrew Karplus, Dr. Gary Merrill, Dr. Weihong Qiu, Dr. Barbara

Part I: Synthetic Studies Towards Viridin, Halenaquinone, and Obtusanal. Part II: Analysis, Synthesis, and Characterization of Coronene Derivatives.

Creator:: Waldenmaier, Pieter K.
Abstract:: This thesis is separated into three distinct projects. First, synthetic studies towards the furanosteroid viridin shown in part I. Second, synthetic studies towards the diperene obtusanal shown in part II. Third, the analysis, characterization, and synthesis of coronene derivatives towards their application in organic batteries shown in part III. Significant...
Resource Type:: Dissertation

Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

Creator:: Narayanappa, Murugesh
Abstract:: Hearing loss is one of the most common defect, affecting 360 million people worldwide due to several factors including congenital, present at or soon after birth or acquired with age. Congenital hearing loss affects 32 million children in the world. The economic impact of hearing loss is estimated to cost...
Resource Type:: Dissertation
Full Text:: . I definitely wouldn’t have kept my sanity without it. I thank my committee members Weihong

ScholarsArchive@OSU

Testing Continuity between Versions 5.3.9 and 6.3.1 of Plaque Simulator for Planning Eye Plaque Brachytherapy Cases

Multi-scale Investigation of Bidirectional Feedback Mechanism Between Breast Cancer Cells and Extracellular Matrix

Electrochemical Micro-sensors for Probing Bacterial Metabolic Behavior with Scanning Electrochemical Microscopy

In vivo Reactions of Tetrazines Incorporated through Genetic Code Expansion

Single-molecule in vitro Characterization of Otoferlin

Nonlinear behavior of thermal and ion transport at the nanoscale

Exploring Protein Structure: Seeing the Forest and the Trees

CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

Mechanics of three-dimensional microenvironments of cells

Information Processing in Multicellular Networks

Refractory Amorphous Metal Thin Films

Initial in vitro and in vivo Characterization of the Membrane Trafficking Protein Fer1L6

Protein Disorder in the Evolution of Dynein Regulation

Part I: Synthetic Studies Towards Viridin, Halenaquinone, and Obtusanal. Part II: Analysis, Synthesis, and Characterization of Coronene Derivatives.

Characterizing the Functional Properties of Otoferlin, Essential for Neurotransmission in Inner Hair Cells of the Cochlea

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