Cryptococcus, a major cause of disseminated infections in immunocompromised patients, kills over 600,000 people per year
worldwide. Genes involved in the virulence of the meningitis-causing fungus are being characterized at an increasing rate, and to
date, at least 648 Cryptococcus gene names have been published. However, these data are scattered...
Quantitative assessments of post-fire effects are key to improving our understanding of ecosystem resilience. While remote sensing technology has allowed us to assess post-fire landscape effects, we are often limited by the lack of information related to pre-fire forest attributes. As a result, our ability to interpret fire effects in...
Intravenous regional limb perfusion (IVRLP) with tiludronate is a commonly used treatment for distal limb orthopedic disease in horses, but doses and protocols are anecdotal. IVRLP exposes articular cartilage within the perfused area to tiludronate, raising concerns about safety of this treatment, as high tiludronate concentrations (≥19mg/L) were harmful for...
There is a perceived trade-off between fire risk reduction and northern spotted owl habitat protection in dry-conifer forests in southwestern Oregon. Management options for balancing this trade-off need to be sought at the landscape level. Applied landscape ecology suggests three important features to consider are (1) patch size and configuration...
Increasingly, objectives for forests with moderate- or mixed-severity fire regimes are to restore successionally diverse landscapes that are resistant and resilient to current and future stressors. Maintaining native species and characteristic processes requires this successional diversity, but methods to achieve it are poorly explained in the literature. In the Inland...
Cyclic nitramines are a class of compounds that include most of the commonly used explosives today. These are among the most common toxicants released into the environment as a result of human activity, generated on military ranges, battlefields, and production sites. Of these, hexahydro-1,3,5-trinitro-1,3,5- triazine (RDX) is of particular interest,...
RNA-Sequencing (RNA-Seq) has rapidly become the de facto technique in transcriptome studies. However, established statistical methods for analyzing experimental and observational microarray studies need to be revised or completely re-invented to accommodate RNA-Seq data's unique characteristics. In this dissertation, we focus on statistical analyses performed at two particular stages in...