Index Catalog // ScholarsArchive@OSU

C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice

Creator:: Kyme, Pierre, Thoennissen, Nils H., Tseng, Ching Wen, Thoennissen, Gabriela B., Wolf, Andrea J., Shimada, Kenichi, Krug, Utz O., Lee, Kunik, Muller-Tidow, Carsten, Berdel, Wolfgang E., Hardy, W. David, Gombart, Adrian F., Koeffler, H. Phillip, and Liu, George Y.
Abstract:: The myeloid-specific transcription factor, CCAAT/enhancer-binding protein epsilon (C/EBPε) is a critical mediator of myelopoiesis. Mutation of this gene is responsible for neutrophil-specific granule deficiency in humans, a condition that confers susceptibility to Staphylococcus aureus infection. We found that C/EBPε-deficient mice are severely affected by infection with S. aureus, and C/EBPε...
Resource Type:: Article
Full Text:: . doi:10.1172/JCI62070. research article The Journal of Clinical Investigation http://www.jci.org

Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

Creator:: Trias, Emiliano, Beilby, Pamela R., Kovacs, Mariangeles, Ibarburu, Sofia, Varela, Valentina, Barreto-Nunez, Romina, Bradford, Samuel C., Beckman, Joseph S., and Barbeito, Luis
Abstract:: Age is a recognized risk factor for amyotrophic lateral sclerosis (ALS), a paralytic disease characterized by progressive loss of motor neurons and neuroinflammation. A hallmark of aging is the accumulation of senescent cells. Yet, the pathogenic role of cellular senescence in ALS remains poorly understood. In rats bearing the ALS-linked...
Resource Type:: Article

Development of Simple, Rapid, and Sensitive qPCR Assay for the Detection of Pseudocapillaria tomentosa in Danio rerio Tissue Samples

Creator:: Ramras, Monique A.
Abstract:: Pseudocapillaria tomentosa is a nematode that parasitizes Danio rerio, causing major disease that affects the economic commodities of fish industries and destroys experimental results at research facilities. There is a critical need for a rapid and sensitive diagnostic assay to test for P. tomentosa in D. rerio populations. PCR primers...
Resource Type:: Honors College Thesis
Full Text:: .” Journal of Clinical Investigation, vol. 122, no. 7, 2 July 2012, pp. 2337–2343., doi:10.1172/jci60434

Remodeling of skeletal muscle mitochondrial proteome with high-fat diet involves greater changes to beta-oxidation than electron transfer proteins in mice

Creator:: Dasari, Surendra, Newsom, Sean A., Ehrlicher, Sarah E., Stierwalt, Harrison D., and Robinson, Matthew M.
Abstract:: Excess fat intake can increase lipid oxidation and expression of mitochondrial proteins, indicating remodeling of the mitochondrial proteome. Yet intermediates of lipid oxidation also accumulate, indicating a relative insufficiency to completely oxidize lipids. We investigated remodeling of the mitochondrial proteome to determine mechanisms of changes in lipid oxidation following high-fat...
Resource Type:: Article

Effects of low and high dose intraarticular tiludronate on synovial fluid and clinical variables in healthy horses—a preliminary investigation

Creator:: Duesterdieck-Zellmer, Katja F., Moneta, Lindsey, Ott, Jesse F., Larson, Maureen K., Gorman, Elena M., Hunter, Barbara, Löhr, Christiane V., Payton, Mark E., Morré, Jeffrey T., and Maier, Claudia S.
Abstract:: To determine effects of intraarticularly administered tiludronate on articular cartilage in vivo, eight healthy horses were injected once with tiludronate (low dose tiludronate [LDT] 0.017 mg, n = 4; high dose tiludronate [HDT] 50 mg, n = 4) into one middle carpal joint and with saline into the contralateral joint....
Resource Type:: Article

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

Creator:: Rouches, Miles V.
Abstract:: The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
Resource Type:: Honors College Thesis
Full Text:: normal glucose homeostasis. Journal of Clinical Investigation. 2006;116(4):1102-1109. doi:10.1172

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis
Full Text:: differentiation through the forkhead transcription factor Foxp1. J Clin Invest 114:408–18. doi: 10.1172/JCI21100

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis
Full Text:: differentiation through the forkhead transcription factor Foxp1. J Clin Invest 114:408–18. doi: 10.1172/JCI21100

Challenges in the Diagnosis and Treatment of Homozygous Familial Hypercholesterolemia

Creator:: Ito, Matthew K. and Watts, Gerald F.
Abstract:: Homozygous familial hypercholesterolemia (HoFH) is a rare, genetic disorder characterized by an absence or impairment of low-density lipoprotein receptor (LDLR) function resulting in significantly elevated low-density lipoprotein cholesterol (LDL-C) levels. The cholesterol exposure burden beginning in utero greatly increases the risk for atherosclerotic cardiovascular disease (ASCVD) and premature death. The...
Resource Type:: Article
Full Text:: :10.1172/JCI107332. 11. Soutar AK, Naoumova RP. Mechanisms of disease: genetic causes of familial

Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS

Creator:: Trias, Emiliano, Díaz-Amarilla, Pablo, Olivera-Bravo, Silvia, Isasi, Eugenia, Drechsel, Derek A., Lopez, Nathan, Bradford, C. Samuel, Ireton, Kyle E., Beckman, Joseph S., and Barbeito, Luis
Abstract:: Microglia and reactive astrocytes accumulate in the spinal cord of rats expressing the Amyotrophic lateral sclerosis (ALS)-linked SOD1ᴳ⁹³ᴬ mutation. We previously reported that the rapid progression of paralysis in ALS rats is associated with the appearance of prolifer- ative astrocyte-like cells that surround motor neurons. These cells, designated as Aberrant...
Resource Type:: Article
Full Text:: . 119, 13–15. doi: 10.1172/JCI38096 Barbeito, L. H., Pehar, M., Cassina, P., Vargas, M. R., Peluffo, H

ScholarsArchive@OSU

C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice

Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

Development of Simple, Rapid, and Sensitive qPCR Assay for the Detection of Pseudocapillaria tomentosa in Danio rerio Tissue Samples

Remodeling of skeletal muscle mitochondrial proteome with high-fat diet involves greater changes to beta-oxidation than electron transfer proteins in mice

Effects of low and high dose intraarticular tiludronate on synovial fluid and clinical variables in healthy horses—a preliminary investigation

The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

Challenges in the Diagnosis and Treatment of Homozygous Familial Hypercholesterolemia

Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS

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