Index Catalog // ScholarsArchive@OSU

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release

Creator:: Dani, Raj K., Schumann, Canan, Taratula, Olena, and Taratula, Oleh
Abstract:: Herein, we report the successful development of a novel nanosystem capable of an efficient delivery and temperature-triggered drug release specifically aimed at cancer. The water-soluble 130.1 ± 0.2 nm iron oxide nanoparticles (IONPs) were obtained via synthesis of a monodispersed iron oxide core stabilized with tetramethylammonium hydroxide pentahydrate (TMAOH), followed...
Resource Type:: Article
Full Text:: nanoparticles for remote-controlled drug release. AAPS PharmSciTech, 15(4), 963-972. doi:10.1208/s12249-014

ROS-Induced Nanotherapeutic Approach for Ovarian Cancer Treatment Based on the Combinatorial Effect of Photodynamic Therapy and DJ-1 Gene Suppression

Creator:: Schumann, Canan, Taratula, Olena, Khalimonchuk, Oleh, Palmer, Amy L., Cronk, Lauren M., Jones, Carson V., Escalante, Cesar A., and Taratula, Oleh
Abstract:: This study represents a novel approach for intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells. To assess the potential of the developed therapy, dendrimer-based...
Resource Type:: Article
Full Text:: . Temperature-tunable iron oxide nanoparticles for remote-controlled drug release. AAPS PharmSciTech 2014;15

Spray drying for erythrocyte preservation at room temperature

Creator:: Leu, Hsuan-Yu
Abstract:: Spray drying has been widely used in food science for long-term storage of products such as powdered milk, and it has recently been used for preservation of more temperature sensitive products such as human blood plasma and single-cell organisms. However, there are no previous reports of successful spray drying of...
Resource Type:: Masters Thesis

On the Role of Particle Size Distribution in Selective Laser Melting of 316L Stainless Steel

Creator:: Coe, Hannah G.
Abstract:: Selective laser melting (SLM) is an additive manufacturing (AM) process that uses a laser beam to melt metal powder as it is spread onto the build surface using a roller or scraper, followed by rapid solidification to manufacture a 3D component, one layer at a time. In SLM process, density...
Resource Type:: Masters Thesis

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Creator:: Schumann, Canan B.
Abstract:: Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
Resource Type:: Dissertation

Investigation of Optimal Extraction Conditions and Microencapsulation Technique for Stabilizing Anthocyanins and Polyphenols from Fruit Materials

Creator:: Wang, Wenjie
Abstract:: The objectives of this research were to investigate the optimal conditions for anthocyanins extraction from different anthocyanin rich fruit and to develop microencapsulation formulation for improving stability of anthocyanin extracts. In the extraction optimization study, two extraction methods, "conventional solvent extraction (CE)" and "ultrasound-assisted extraction (UE)" for three different anthocyanin-rich...
Resource Type:: Masters Thesis

Comprehensive, Low-Cost Wicking Microfluidic Analytical Devices for Clinical Diagnostics and Environmental Analysis

Creator:: Bandara, Gayan C.
Abstract:: Analytical techniques are utilized in a wide variety of applications. Traditionally, analytical measurements are achieved by trained personnel in a laboratory setting using expensive scientific instruments, which limits their applicability in resource-limited areas and point-of-care applications. Therefore, the concept of enabling these laboratory-based qualitative and quantitative assays in microfluidic device...
Resource Type:: Dissertation

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Creator:: Doddapaneni, Bhuvana S.
Abstract:: Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
Resource Type:: Dissertation

Pressure sensitive adhesives based on oleic acid

Creator:: Wu, Yili
Abstract:: Existing pressure sensitive adhesives (PSAs) are mostly based on petrochemicals. In this study, a novel PSA based on a renewable material, methyl oleate, was prepared and characterized. Methyl oleate was first epoxidized to form epoxidized methyl oleate that was subsequently hydrolyzed and acidified to form epoxidized oleic acid (EOA) which...
Resource Type:: Masters Thesis

Tuning Functional Properties of Pyrochlore and Related Oxides via Cation and Anion Substitutions

Creator:: Giampaoli, Gabriella C. S.
Abstract:: Inorganic structures play an important role in materials due to their versatility and diversity. A complete understanding of the structure of a material is vital to enhance the creation of new materials that fill voids in research. The rational design of these compounds is driven by the exploitation of structure-property...
Resource Type:: Dissertation

ScholarsArchive@OSU

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release

ROS-Induced Nanotherapeutic Approach for Ovarian Cancer Treatment Based on the Combinatorial Effect of Photodynamic Therapy and DJ-1 Gene Suppression

Spray drying for erythrocyte preservation at room temperature

On the Role of Particle Size Distribution in Selective Laser Melting of 316L Stainless Steel

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Investigation of Optimal Extraction Conditions and Microencapsulation Technique for Stabilizing Anthocyanins and Polyphenols from Fruit Materials

Comprehensive, Low-Cost Wicking Microfluidic Analytical Devices for Clinical Diagnostics and Environmental Analysis

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Pressure sensitive adhesives based on oleic acid

Tuning Functional Properties of Pyrochlore and Related Oxides via Cation and Anion Substitutions

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