In 2017, the cost of congestion in the United States was around 305 billion dollars, and city-dwellers, on average, lost 1400 dollars while sitting 42 hours in traffic jams. Aiming for better mobility and more efficient utilization of the transportation network, emerging connected and autonomous vehicle (CAV) technologies and their...
The overall focus of this thesis is on the distribution of specific lipids and membrane proteins of the external and internal membranes of plant cells, in the context of the roles that those lipids and proteins may play in microbe-plant interactions. The work includes the development of several new tools,...
This work is inspired by problems in natural resource management centered on the challenge of invasive species. Computing optimal management policies for maintaining ecosystem sustainable is challenging. Many ecosystem management problems can be formulated as MDP (Markov Decision Process) planning problems. In a simulator-defined MDP, the Markovian dynamics and rewards...
Markov Decision Processes (MDPs) are the de-facto formalism for studying sequential decision making problems with uncertainty, ranging from classical problems such as inventory control and path planning, to more complex problems such as reservoir control under rainfall uncertainty and emergency response optimization for fire and medical emergencies. Most prior research...
Autonomous multiagent teams can be used in complex exploration tasks to both expedite the exploration and improve the efficiency. However, use of multiagent systems presents additional challenges. Specifically, in domains where the agents' actions are tightly coupled, coordinating multiple agents to achieve cooperative behavior at the group level is difficult....
Writing a program that performs well in a complex environment is a challenging task. In such problems, a method of deterministic programming combined with reinforcement learning (RL) can be helpful. However, current systems either force developers to encode knowledge in very specific forms (e.g., state-action features), or assume advanced RL...
Novel broad-spectrum antimicrobials are a critical component of a strategy for combating antibiotic-resistant pathogens. In this
study, we explored the activity of the broad-spectrum antiviral compound ST-669 for activity against different intracellular bacteria
and began a characterization of its mechanism of antimicrobial action. ST-669 inhibits the growth of three different...
This thesis considers the problem in which a teacher is interested in teaching action policies to computer agents for sequential decision making. The vast majority of policy
learning algorithms o er teachers little flexibility in how policies are taught. In particular,
one of two learning modes is typically considered: 1)...
We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as
B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity
of morpholino phosphorodiamidate oligomers (PMOs) in dystrophin-deficient mdx mice. In the present study, the general
mechanistic significance of the...
How can an agent generalize its knowledge to new circumstances? To learn
effectively an agent acting in a sequential decision problem must make intelligent action selection choices based on its available knowledge. This dissertation focuses on Bayesian methods of representing learned knowledge and develops novel algorithms that exploit the represented...