The thrust of this thesis is to study oral solid dosage formulation using hot melt coating method and to use pharmacokinetic modeling and simulation (PK M&S) as a tool that can help to predict pharmacokinetics of a drug in human and the probability of passing various bioequivalence criteria of the...
We examined the characteristics of biological patches at four different locations to assess the relationship of patch vertical scale, amplitude, and persistence. In contrast to patches of larger animals, we found that the majority of coherent aggregations of plankton at each site were vertically compressed, with most smaller than 5m...
Heavy biodegraded crude oils have larger numbers of coeluting compounds than non- biodegraded oils, and they are typically not resolved with conventional gas chromatography (GC). This unresolved complex mixture (UCM) has been investigated using comprehensive two- dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-ToFMS) within a set of biodegraded petroleums derived from...
Multi-instance data, in which each object (e.g., a document) is a collection of instances
(e.g., word), are widespread in machine learning, signal processing, computer vision,
bioinformatic, music, and social sciences. Existing probabilistic models, e.g., latent
Dirichlet allocation (LDA), probabilistic latent semantic indexing (pLSI), and discrete
component analysis (DCA), have been...
WRESTORE (Watershed Restoration Using Spatio-Temporal Optimization of Resources) is a web-based, participatory planning tool that can be used to engage with watershed stakeholder communities, and involve them in using science-based, human-guided, interactive simulation–optimization methods for designing potential conservation practices on their landscape. The underlying optimization algorithms, process simulation models, and...
Three-dimensional laser scanning has revolutionized spatial data acquisition and can be completed from a variety of platforms including airborne (ALS), mobile (MLS), and static terrestrial (TLS) laser scanning. MLS is a rapidly evolving technology that provides increases in efficiency and safety over static TLS, while still providing similar levels of...
This dissertation seeks to contribute to a growing body of research on student outcomes by way of a public health perspective examining the intersection of education policy and adolescent mental health and well-being. The conceptual approach underpinning this project rests on the key theoretical assumption that education policy, shaped at...
Passive sampling devices have been used for decades to measure complex mixtures of bioavailable organic chemicals in a variety of environmental media. More recently passive sampler applications have expanded beyond monitoring chemical concentrations, and this dissertation continues to advance methods of passive sampling on many fronts. Despite their growing use,...