Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...
A more quantitative understanding of peptide entrapment and elution from otherwise protein-repellent polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. Here we describe criteria for peptide integration and structural change within the PEO brush, and discuss the reversibility of peptide...
Small organizations may face several management challenges, such as developing non-centralized management structures, knowledge retention in rapid turnover environments, complex operations, and diverse stakeholder requirements. Many methodologies exist to address such management challenges, including viable system model, knowledge management, and Toyota production system, or lean manufacturing. Each of these methodologies...