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Filtering by: Committee Member Humprey, Philip E. Remove constraint Committee Member: Humprey, Philip E. Decade 2010-2019 Remove constraint Decade: 2010-2019

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  • Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

    Creator:
    Nazari, Mohamad
    Abstract:
    Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...
    Resource Type:
    Dissertation
    Full Text:
    of known mandelalides A-D and identification of new congeners E-L from re-collected South African

  • Development of Methods for Stereoselective Carbon-Carbon Bond Formation

    Creator:
    Wu, Zhenhua
    Abstract:
    Three distinct methods to achieve the stereoselective synthesis of carbon-carbon bonds were investigated, encompassing: (i) the formation of axially chiral biaryl molecules by enantioselective Suzuki cross-coupling, (ii) the synthesis of α-phenylalkylboronic esters by enantioselective chain extension, and (iii) the stereospecific synthesis of alkenes by eliminative cross-coupling of enantioenriched sp³-hybridized carbenoids....
    Resource Type:
    Dissertation
    Full Text:
    the targeted alkene [(E)- or (Z)- isomer] as determined by choice of carbenoid stereochemical pairing