Index Catalog // ScholarsArchive@OSU

Creator:: Yin, HaiFang, Boisguerin, Prisca, Moulton, Hong M., Betts, Corinne, Seow, Yiqi, Boutilier, Jordan, Wang, Qingsong, Walsh, Anthony, Lebleu, Bernard, and Wood, Matthew J. A.
Abstract:: We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of morpholino phosphorodiamidate oligomers (PMOs) in dystrophin-deficient mdx mice. In the present study, the general mechanistic significance of the...
Resource Type:: Article

Creator:: Moulton, Hong M.
Abstract:: Morpholino oligos (Morpholinos) are widely used tools for knocking down gene expression and are currently in a clinical trial for treatment of Duchene muscular dystrophy. A Morpholino analog has been in a clinical trial as a potential anti-bioterrorism agent for inhibiting replication of deadly Marburg viral infection. The cellular uptake...
Resource Type:: Article
Full Text:: . Iversen, B. Lebleu, Vectorization of morpholino oligomers by the (R-Ahx-R)4 peptide allows efficient

Creator:: Weinman, Marcus
Abstract:: Many humans and canines alike suffer from osteosarcoma, which is often metastatic, resistant to chemotherapy, and frequently fatal. The mechanisms through which osteosarcoma cells acquire resistance to chemotherapy are not entirely understood, and the role of exosomes as intercellular mediators of this resistance in osteosarcoma is unknown. Using established canine...
Resource Type:: Masters Thesis

ScholarsArchive@OSU