Index Catalog // ScholarsArchive@OSU

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Creator:: Larsen, Christine A.
Abstract:: Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Resource Type:: Dissertation
Full Text:: . David Williams and Dr. Claudia Maier. Thank you for all of your advice and suggestions. You played

Biophysical analyses of peroxiredoxins and a partner reductase

Creator:: Hall, Andrea Renée
Abstract:: Peroxiredoxins (Prxs) are dominant peroxide-reducing enzymes with two important roles: they protect all organisms from oxidative damage induced by peroxides, and in eukaryotes, they participate in hydrogen peroxide signaling pathways. This dissertation presents studies aimed at the biophysical characterization of select Prxs and a Prx reductase to elucidate their structure-function...
Resource Type:: Dissertation
Full Text:: Trempy, Claudia Maier and Martin Schuster for your interest in my development as a scientist. I

Bacterial hydrophobicity : assessment techniques, applications and extension to colloids

Creator:: Saini, Gaurav
Abstract:: This research details laboratory assessment of bacterial hydrophobicity, variations in bacterial adhesion properties with growth and extended starvation as well as extension of this assay to colloidal hydrophobicity measurement. Hydrophobicity is an integral component of surface interactions and has been studied extensively for its role in a number of engineering...
Resource Type:: Dissertation
Full Text:: of my doctoral committee- Profs. Jeff Nason, Jack Istok, and Claudia Maier for their time. I would

Analytical method development for the identification, detection, and quantification of emerging environmental contaminants in complex matrices

Creator:: Place, Benjamin J.
Abstract:: The development of analytical methods for emerging contaminants creates many unique challenges for analytical chemists. By their nature, emerging contaminants have inherent data gaps related to their environmental occurrence, fate, and impact. This dissertation is a compilation of three studies related to method development for the structural identification of emerging...
Resource Type:: Dissertation
Full Text:: . In addition, I would like to recognize my graduate committee: Dr. Stacey Harper, Dr. Claudia

Application of modern NMR techniques to structure elucidation of bioactive natural products from tunicates

Creator:: Sikorska, Justyna
Abstract:: Recent developments in NMR hardware have extended the reach of natural products chemists to structure elucidation of compounds isolated on a nanomolar scale. In parallel with advances in hardware new NMR techniques for structure elucidation have evolved, e.g. quantitative NOEs, residual dipolar couplings (RDCs)and diffusion-ordered spectroscopy (DOSY). The application of...
Resource Type:: Dissertation

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Creator:: Gómez Ramirez, Luis A.
Abstract:: Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...
Resource Type:: Dissertation
Full Text:: research committee, Drs. Claudia S. Maier, Balz Frei, Joseph Beckman and Adam Higgins not only for

The atmospheric chemistry of particulate-bound polycyclic aromatic hydrocarbons : concentration, prediction, laboratory studies, and mutagenicity

Creator:: Jariyasopit, Narumol
Abstract:: The trans-Pacific atmospheric transport of particulate matter (PM)-bound polycyclic aromatic hydrocarbons (PAHs) to remote sites in western North America has been well documented and has triggered research questions regarding to atmospheric transformation of PM-bound PAHs and the potential impacts on human health from their inhalation exposure. In this dissertation, field...
Resource Type:: Dissertation
Full Text:: . William Baird, Dr. Jennifer Field, Dr. Claudia Maier and Dr. Fredrick Prahl, Dr. Paul Ha-Yeon Cheong for

Molecular origins of peptide entrapment in polyethylene oxide layers

Creator:: Wu, Xiangming
Abstract:: A more quantitative understanding of peptide entrapment and elution from otherwise protein-repellent polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. Here we describe criteria for peptide integration and structural change within the PEO brush, and discuss the reversibility of peptide...
Resource Type:: Dissertation
Full Text:: McPhail, Dr. Victor Hsu and Dr. Claudia Maier for all the valuable discussion about my research and for

Human exposure to polycyclic aromatic hydrocarbons : global cancer risk and metabolism

Creator:: Motorykin, Oleksii
Abstract:: In recent decades, there has been increased attention on human exposure to, and subsequently toxicity of, Polycyclic Aromatic Hydrocarbons (PAHs). PAHs are widespread organic pollutants and some have been shown to be toxic, carcinogenic and mutagenic. This research was focused on understanding the link between global PAH emissions and lung...
Resource Type:: Dissertation
Full Text:: committee members, Dr. Jennifer Field, Dr. Claudia Maier and Dr. William Baird, Dr. Victor Hsu and Dr

Improving in vitro mineral nutrition for diverse red raspberry and Rubus germplasm

Creator:: Poothong, Sukalya
Abstract:: Red raspberry, Rubus idaeus L., is a valuable crop for the U.S. Pacific Northwest and clonal propagation is required to produce disease-free plants and for germplasm preservation. One challenge of red raspberry micropropagation is the wide variation in growth response among the cultivars. The studies described in this dissertation were...
Resource Type:: Dissertation
Full Text:: . Milligan, Prof. Claudia S. Maier, and Prof. Thomas Chastain for knowledgeable encouragement, assistance

ScholarsArchive@OSU

Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

Biophysical analyses of peroxiredoxins and a partner reductase

Bacterial hydrophobicity : assessment techniques, applications and extension to colloids

Analytical method development for the identification, detection, and quantification of emerging environmental contaminants in complex matrices

Application of modern NMR techniques to structure elucidation of bioactive natural products from tunicates

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

The atmospheric chemistry of particulate-bound polycyclic aromatic hydrocarbons : concentration, prediction, laboratory studies, and mutagenicity

Molecular origins of peptide entrapment in polyethylene oxide layers

Human exposure to polycyclic aromatic hydrocarbons : global cancer risk and metabolism

Improving in vitro mineral nutrition for diverse red raspberry and Rubus germplasm

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