The effects of alfaxalone (A-HPCD), propofol (P), ketamine-diazepam (KD) and tiletamine-zolazepam (TZ) administered IV in dogs on cardiovascular and respiratory systems, acid-base balance and electrolytes have been reported in the literature, but a study that compares IV TZ to the other induction protocols (IP) is needed. Six dogs enrolled in...
Alfaxalone (3a-hydroxy-5a-pregnane-11,20-dione) is a neuroactive steroid that can induce anesthesia. It has recently been reformulated and solubilized in 2-hydroxypropyl-β-cyclodextrin (HCPD). Propofol and the combination of ketamine and diazepam are commonly used induction drugs in all species. The objective of this prospective randomized and crossover design study was to evaluate the...
Since the early twentieth century, manufacturers of toxic products have attempted
to discredit research linking their product with disease. At the same time they have manufactured their own science designed to minimize risks associated with their products. Much of this activity has been conducted by or through corporate attorneys, endeavors...