Index Catalog // ScholarsArchive@OSU

A robust Mycobacterium smegmatis Assay for the Discovery of Anti-tubercular Metabolites from Soil Bacteria

Creator:: Chen, Kathryn P
Abstract:: Tuberculosis (TB) is a pressing global health issue with approximately one third of the world’s population infected by this bacterium. As one of the most dangerous infectious diseases, it has killed approximately 1.7 million people of all ages around the world per year (World Health Organization, 2016). Currently, several drugs...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kerry McPhail, Committee Member, representing Pharmaceutical Sciences

Investigation of microbial extracts as a source of neurological agents

Creator:: Malmo, Jay M.
Abstract:: This study tested natural products from cyanobacteria from the Red Sea in Egypt and marine tunicates from the Algoa Bay in South Africa. Products from marine organisms have been used as lead compounds for the synthesis of new drugs because of their biological activity mechanism. Specifically, these products may contain...
Resource Type:: Research Paper

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:: Snyder, Kevin M.
Abstract:: In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
Resource Type:: Masters Thesis
Full Text:: . Kerry L. McPhail, and Prof. Paul Ha-Yeon Cheong contributed in part to the preparation and review of

Synthesis, characterization, and analysis of nitroaromatic compounds

Creator:: McIntosh, Melissa Luana
Abstract:: Nitroaromatic compounds have important chemical applications and can be found in nature as pollution sources. Synthetic nitroaromatic compounds have been used in a variety of materials including explosives, pharmaceuticals, dyes, plastics, and pesticides. These compounds can find their way into the environment through normal or improper disposal methods. Poly-aromatic compounds...
Resource Type:: Masters Thesis
Full Text:: two such brilliant professionals. I would like to thank my committee members Professor Kerry

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Creator:: Overacker, Ross D.
Abstract:: Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Resource Type:: Dissertation

Secondary Metabolism in Tolypocladium : Characterization, Ecology, Evolution and Regulation

Creator:: Blount, Rheannon Rua
Abstract:: An increased understanding of secondary metabolism in fungi is important for both biological and societal reasons. The ascomycete genus, Tolypocladium, is an ideal system to explore secondary metabolism characterization, ecology, evolution and regulation. The genus produces and has the genomic potential to produce a wide array of metabolites. Paired with...
Resource Type:: Dissertation
Full Text:: patience in that lab. Kerry McPhail was a close second advisor though this process. With her support

Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

Creator:: Wan, Xuemei
Abstract:: Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...
Resource Type:: Dissertation
Full Text:: express my gratitude to Dr. Kerry McPhail for being an active and supportive collaborator. I also wish

Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

Creator:: Brumsted, Corey J.
Abstract:: Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
Resource Type:: Dissertation

Single-Cell Genomics of Uncultivated Marine Bacteria

Creator:: Landry, Zachary
Abstract:: Historically, the difficulty of obtaining pure cultures of abundant marine microbial plankton has an obstacle to reconstructing the underlying mechanisms of biogeochemistry in the ocean. While a number of dominant marine species from the ocean surface have been cultured, the dominant microbial plankton of the dark ocean proved far more...
Resource Type:: Dissertation

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:: Huang, Lin
Abstract:: Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
Resource Type:: Dissertation
Full Text:: University. I would like to thank all my committee members, Dr Chrissa Kioussi, Dr Kerry McPhail, Dr Chong

ScholarsArchive@OSU

A robust Mycobacterium smegmatis Assay for the Discovery of Anti-tubercular Metabolites from Soil Bacteria

Investigation of microbial extracts as a source of neurological agents

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Synthesis, characterization, and analysis of nitroaromatic compounds

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Secondary Metabolism in Tolypocladium : Characterization, Ecology, Evolution and Regulation

Natural Products as Pharmacological Tools to probe Mitochondrial and Secretory Function in Cancer Cells

Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

Single-Cell Genomics of Uncultivated Marine Bacteria

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search