Index Catalog // ScholarsArchive@OSU

Myths, Artifacts, and Fatal Flaws: Identifying Limitations and Opportunities in Vitamin C Research

Creator:: Michels, Alexander J. and Frei, Balz
Abstract:: Research progress to understand the role of vitamin C (ascorbic acid) in human health has been slow in coming. This is predominantly the result of several flawed approaches to study design, often lacking a full appreciation of the redox chemistry and biology of ascorbic acid. In this review, we summarize...
Resource Type:: Article
Full Text:: : Identifying Limitations and Opportunities in Vitamin C Research Alexander J. Michels * and Balz Frei

Inhibition of pancreatic lipase by grape seed and tea extracts and their primary catechins in vitro

Creator:: Hess, Michelle M., Michels, Alexander J., and Frei, Balz
Abstract:: Inhibiting pancreatic lipase activity is an effective means of reducing fat absorption, which may have a role in combating obesity by limiting energy intake. The use of pharmaceutical lipase inhibitors has been limited due to the prevalence of undesirable side effects. Polyphenols represent an alternative strategy to inhibit digestive enzymes...
Resource Type:: Poster

An epigenetic perspective on pharmacologic ascorbate in colon cancer

Creator:: Kaiser, Matthew Carl, Rajendran, Praveen, Dashwood, Mohaiza W., Levine, Mark A., Michels, Alexander, Frei, Balz, and Dashwood, Roderick H.
Abstract:: Aim: There is growing interest in pharmacologic ascorbate (Asc) and its therapeutic properties (Levine et al. Adv Nutr 2011;2:78). W e examined cell viability, histone deacetylase (HDAC) expression, and related protein modifications in cancer versus non- cancer colon epithelial cells following exposure to Asc. Methods: MTT assays were conducted in...
Resource Type:: Video, Presentation, and Other

Finding Our Way through Phenotypes

Creator:: Deans, Andrew R., Lewis, Suzanna E., Huala, Eva, Anzaldo, Salvatore S., Ashburner, Michael, Balhoff, James P., Blackburn, David C., Blake, Judith A., Burleigh, J. Gordon, Chanet, Bruno, Cooper, Lauren D., Courtot, Mélanie, Csösz, Sándor, Cul, Hong, Dahdul, Wasila, Das, Sandip, Dececchi, T. Alexander, Dettal, Agnes, Diogo, Rui, Druzinsky, Robert E., Dumontier, Michel, Franz, Nico M., Friedrich, Frank, Gkoutos, George V., Haendel, Melissa, Harmon, Luke J., Hayamizu, Terry F., He, Yongqun, Hines, Heather M., Ibrahim, Nizar, Jackson, Laura M., Jaiswal, Pankaj, James-Zorn, Christina, Köhler, Sebastian, Lecointre, Guillaume, Lapp, Hilmar, Lawrence, Carolyn J., Le Novère, Nicolas, Lundberg, John G., Macklin, James, Mast, Austin R., Midford, Peter E., Mikó, István, Mungall, Christopher J., Oellrich, Anika, Osumi-Sutherland, David, Parkinson, Helen, Ramírez, Martín J., Richter, Stefan, Robinson, Peter N., Ruttenberg, Alan, Schulz, Katja S., Segerdell, Erik, Seltmann, Katja C., Sharkey, Michael J., Smith, Aaron D., Smith, Barry, Specht, Chelsea D., Squires, R. Burke, Thacker, Robert W., Thessen, Anne, Fernandez-Triana, Jose, Vihinen, Mauno, Vize, Peter D., Vogt, Lars, Wall, Christine E., Walls, Ramona L., Westerfeld, Monte, Wharton, Robert A., Wirkner, Christian S., Woolley, James B., Yoder, Matthew J., Zorn, Aaron M., and Mabee, Paula
Abstract:: Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across...
Resource Type:: Article
Full Text:: Csösz14, Hong Cui15, Wasila Dahdul16, Sandip Das17, T. Alexander Dececchi16, Agnes Dettai11, Rui Diogo18

A Mystical Metamorphosis: Conceptualizing the Extraordinary in the Mundane Through Land Art

Creator:: McClarence, Shoshana H.
Abstract:: Mystical experiences are ineffable, thus defining mysticism itself is a difficult feat. To aid in the construction of a definition of mysticism it is imperative to break down the unique elements of a mystical experience and try to give examples of where we can see all of these elements interacting....
Resource Type:: Masters Thesis
Full Text:: to delineate mysticism through genealogy was missing something; Michel Foucault’s genealogy makes

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Creator:: Monette, Jeffrey S.
Abstract:: Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
Resource Type:: Dissertation
Full Text:: Smith, Alexander Michels, and Brian Dixon, I thank you for your friendship, advice, and for teaching

Quantification of state-and-transition model components utilizing long-term ecological response data following one-seed juniper treatment on a deep sand savannah ecological site

Creator:: Shaver, Patrick L.
Abstract:: A proposed state-and-transition model (STM) for the Deep Sand Savannah ecological site in central New Mexico was developed using historical data and expert knowledge. This STM was tested utilizing data from short and long term one-seed juniper (Juniperus monosperma (Engelm.) Sarg.) control experiments initiated in 1981 and 1985. Utilizing data...
Resource Type:: Dissertation
Full Text:: Alexander 1974, Schott and Pieper 1986). Trees as short as 46 cm in height can produce seed (Johnsen 1962

Nonthermal Plasma Microreaction Engineering for Gas and Liquid Processing

Creator:: Pommerenck, Justin
Abstract:: Atmospheric pressure plasma is non-thermal at millimeter to micrometer separations. It represents an alternative low exergy initiator of many chemical reactions. In many instances heat, light or sound are not efficient providers of the necessary energy to overcome chemical activation barriers. The focus of this research is applying dc nonthermal...
Resource Type:: Dissertation

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Creator:: Li, Chuan
Abstract:: Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...
Resource Type:: Dissertation
Full Text:: the members of the Balz Frei lab, especially Dr. Alexander Michels, Bob Durst and Deborah Hobbs, for

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

Creator:: Smith, Eric Jonathan
Abstract:: Nuclear Factor, Erythroid Derived 2, Like 2 (NFE2L2 or Nrf2) is the primary transcription factor in cellular defense against oxidative and xenobiotic stresses in higher eukaryotes. This basic leucine zipper transcription factor regulates over 200 antioxidant, detoxification, and lipid metabolizing genes by binding to the Antioxidant Response Element (ARE; a...
Resource Type:: Dissertation
Full Text:: Thomas, Liam Finley, Drs. Kate Shay, Dove Keith, Jeff Monette, Luis Gomez, and Alex Michels. Finally

ScholarsArchive@OSU

Myths, Artifacts, and Fatal Flaws: Identifying Limitations and Opportunities in Vitamin C Research

Inhibition of pancreatic lipase by grape seed and tea extracts and their primary catechins in vitro

An epigenetic perspective on pharmacologic ascorbate in colon cancer

Finding Our Way through Phenotypes

A Mystical Metamorphosis: Conceptualizing the Extraordinary in the Mundane Through Land Art

A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

Quantification of state-and-transition model components utilizing long-term ecological response data following one-seed juniper treatment on a deep sand savannah ecological site

Nonthermal Plasma Microreaction Engineering for Gas and Liquid Processing

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Age-related loss of Nrf2, a novel mechanism for the potential attenuation of xenobiotic detoxification capacity

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