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Filtering by: Subject Proteins -- Spectra Decade 2010-2019

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Creator:

Wang, Jing

Abstract:

Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...

Resource Type:

Dissertation

Full Text:

-iodobutyl)triphenyl- phosphonium (IBTP), was used to label the protein thiols. This study was focused on
Mass-spectrometric Methods for Quantitative Proteomics and Post-translational Modification Mapping

Creator:

Motorykin, Ievgen

Abstract:

Signal transduction within and between cells is at the core of biological activity in all living systems. Signaling networks are required for regulating biological functions, including growth, development and survival. Deregulation of signaling cascades has been linked to chronic and acute diseases and disorders This thesis focuses on mass spectrometry...

Resource Type:

Dissertation