Index Catalog // ScholarsArchive@OSU

Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment

Creator:: Yang, Xiuqing, Feng, Peng, Yin, Ying, Bushley, Kathryn, Spatafora, Joseph W., and Wang, Chengshu
Abstract:: The cycloundecapeptide cyclosporin A (CsA) was first isolated from the insect-pathogenic fungus Tolypocladium inflatum for its antifungal activity and later developed as an immunosuppressant drug. However, the full biosynthetic mechanism of CsA remains unknown and has puzzled researchers for decades. In this study, the biosynthetic gene cluster is suggested to...
Resource Type:: Article
Full Text:: Benefits Fungal Adaptation to the Environment Xiuqing Yang,a,b Peng Feng,a Ying Yin,a Kathryn Bushley,c

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

Creator:: Hu, Zhiwei, Brooks, Samira A., Dormoy, Valérian, Hsu, Chia-Wen, Hsu, Hsue-Yin, Lin, Liang-Tzung, Massfelder, Thierry, Rathmell, W. Kimryn, Xia, Menghang, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G., Prudhomme, Kalan R., Colacci, Annamaria, Hamid, Roslida A., Mondello, Chiara, Raju, Jayadev, Ryan, Elizabeth P., Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Lowe, Leroy, Jensen, Lasse, Bisson, William H., and Kleinstreuer, Nicole
Abstract:: One of the important ‘hallmarks’ of cancer is angiogenesis, which is the process of formation of new blood vessels that are necessary for tumor expansion, invasion and metastasis. Under normal physiological conditions, angiogenesis is well balanced and controlled by endogenous proangiogenic factors and antiangiogenic factors. However, factors produced by cancer...
Resource Type:: Article
Full Text:: Dormoy2,3, Chia-Wen Hsu4, Hsue-Yin Hsu5, Liang-Tzung Lin6, Thierry Massfelder2, W. Kimryn Rathmell1

Expansion of the Tibetan Plateau during the Neogene

Creator:: Wang, Weitao, Zheng, Wenjun, Zhang, Peizhen, Li, Qiang, Kirby, Eric, Yuan, Daoyang, Zheng, Dewen, Liu, Caicai, Wang, Zhicai, Zhang, Huiping, and Pang, Jianzhang
Abstract:: The appearance of detritus shed from mountain ranges along the northern margin of the Tibetan Plateau heralds the Cenozoic development of high topography. Current estimates of the age of the basal conglomerate in the Qaidam basin place this event in Paleocene-Eocene. Here we present new magnetostratigraphy and mammalian biostratigraphy that...
Resource Type:: Article
Full Text:: strata have been subdivided into seven primary stratigraphic units: the Lulehe, Xia Ganchaigou, Shang

Addressing Persistent Challenges in Nanotoxicology Exposures : Techniques for in situ Characterization

Creator:: Crandon, Lauren E.
Abstract:: Nanoparticles (NPs), defined by their size (1-100 nm), are increasingly incorporated into commercial and industrial products due to their high surface area and unique properties. They can be designed for specific applications by manipulating composition, size, shape, and surface functionalization. As NP production and complexity increases, there is a need...
Resource Type:: Dissertation

Quantum dot plasmon coupling : Fundamental study and applications

Creator:: Kannegulla, Akash
Abstract:: The dissertation focuses on the engineering of light-matter interaction using plasmonic nanoparticles and metamaterials to achieve enhanced luminescence and based on which to improve the performance of biosensing and light-emitting technologies. We designed and fabricated a spectrum of nanostructures to exhibit particular dispersion relations capable of controlling the spontaneous emission...
Resource Type:: Dissertation

WiFO: A hybrid communication network based on integrated free-space optical and WiFi femtocells

Creator:: Liverman, Spencer, Wang, Qiwei, Chu, Yu-Jung, Borah, Anindita, Wang, Songtao, Natarajan, Arun, Wang, Alan X., and Thinh Nguyen
Abstract:: Developments in smart home technology and the Internet of Things have significantly increased the demand for high-speed indoor wireless links. Although the majority of the research conducted in this area is still focused on the efficient usage of radio frequency (RF) spectrum, free-space optical (FSO) networks have also been explored...
Resource Type:: Article
Full Text:: . Chi, J. Yu, H. Shang, Demonstration of 575- mb/s downlink and 225-mb/s uplink bi-directional scm-wdm

Evaluation of amorphous oxide semiconductors for thin film transistors (TFTs) and resistive random access memory (RRAM) applications

Creator:: Rajachidambaram, Jaana Saranya
Abstract:: Thin-film transistors (TFTs) are primarily used as a switching element in liquid crystal displays. Currently, amorphous silicon is the dominant TFT technology for displays, but higher performance TFTs will become necessary to enable ultra-definition resolution high-frequency large-area displays. Amorphous zinc tin oxide (ZTO) TFTs were fabricated by RF magnetron sputter...
Resource Type:: Masters Thesis

Systematic, genomic, and transcriptomic analysis of mycoparasitic Tolypocladium species and their Elaphomyces hosts

Creator:: Quandt, C. Alisha
Abstract:: Fungi in the genus Tolypocladium are diverse in their host associations, but the predominant ecologies include parasites of the ectomycorrhizal genus Elaphomyces and pathogens of insects. The aim of this dissertation research is to examine the evolution of these fungi and their host associations. To accomplish this several lines of...
Resource Type:: Dissertation

Bioprospecting the Chemical Diversity of Plant-associated Fungi

Creator:: González-Montiel, Gisela Abigail
Abstract:: Fungi have long been used for discovery of new chemical scaffolds. In the clinical setting, the fungal natural products penicillin, statins, and cyclosporine have revolutionized medicine to treat diseases and infections. In the environment, fungal natural products have been used as herbicides, fungicides, and insecticides to protect crops, livestock, and...
Resource Type:: Masters Thesis

Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

Creator:: Adpressa, Donovon A.
Abstract:: Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
Resource Type:: Dissertation
Full Text:: , 701. 40. Overy, D.; Correa, H.; Roullier, C.; Chi, W.-C.; Pang, K.-L.; Rateb, M.; Ebel, R.; Shang

ScholarsArchive@OSU

Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

Expansion of the Tibetan Plateau during the Neogene

Addressing Persistent Challenges in Nanotoxicology Exposures : Techniques for in situ Characterization

Quantum dot plasmon coupling : Fundamental study and applications

WiFO: A hybrid communication network based on integrated free-space optical and WiFi femtocells

Evaluation of amorphous oxide semiconductors for thin film transistors (TFTs) and resistive random access memory (RRAM) applications

Systematic, genomic, and transcriptomic analysis of mycoparasitic Tolypocladium species and their Elaphomyces hosts

Bioprospecting the Chemical Diversity of Plant-associated Fungi

Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

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