Index Catalog // ScholarsArchive@OSU

Development and broad application of a mass spectrometry based metabolomics platform

Creator:: Kirkwood, Jay Steven
Abstract:: Metabolomics is a comprehensive analysis of small molecules, or metabolites, in a system. Metabolomics is a hypothesis-generating experiment and offers an unbiased analysis of cell metabolism that can aid in the understanding of fundamental biological processes. Metabolomics is widely and broadly applicable in the biological sciences and has been used...
Resource Type:: Dissertation
Full Text:: chromatography-quadrupole-time-of-flight mass spectrometry metabolomics platform and details the various steps

The identification and quantitation of complex polycyclic aromatic hydrocarbon mixtures in environmental samples using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry

Creator:: Manzano, Carlos A.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants and are mostly products of the incomplete combustion of organic material. PAHs are often found in environmental samples as a complex mixture of isomers. In addition, the same sources that produce complex PAH mixtures also produce other poorly characterized mixtures of organic compounds,...
Resource Type:: Dissertation
Full Text:: Chromatography with Time-of-flight Mass Spectrometry Abstract approved: Staci L. Massey Simonich

From fossils to phylogenies

Creator:: Goodwin, Baylee N., Besser, August D., and Ramsey, Stephen A.
Abstract:: The research question address in this study is, “To what extent will the use of hands-on activities for introducing concepts in bioinformatics promote student engagement in after-school STEM club settings?” It is hypothesized that high school students' engagement in hands-on bioinformatics activities promotes their awareness of, and interest in, STEM...
Resource Type:: Learning Object and Presentation
Full Text:: ability to discuss and debate the ethics of scientific endeavors. 2. Mass Spectrometry Activity- Using

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:: Huang, Lin
Abstract:: Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
Resource Type:: Dissertation
Full Text:: memory. Firstly, we explored the applicability of travelling wave ion mobility mass spectrometry

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Resource Type:: Article

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Creator:: Wang, Jing
Abstract:: Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
Resource Type:: Dissertation
Full Text:: commonly used mass analyzers in this field include the quadrupole (Q), ion trap (IT), time-of-flight (TOF

Spatiotemporal Phytohormone Distributions in Developing Pinot Noir Berries and the Effects of Two Viticulture Practices Thereon

Creator:: Schmidt, Joseph A.
Abstract:: In recent years, many studies have focused on the molecular and biochemical mechanisms regulating the development of wine grapes. The course of grape berry development is directed by genetic design and is mediated by phytohormones, which regulate grape berry growth and development by orchestrating a complex network of interacting genes,...
Resource Type:: Masters Thesis
Full Text:: . Liquid chromatography coupled to tandem mass spectrometry was then used to analyze the extracted

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Creator:: Nirudodhi, Sasidhar N.
Abstract:: Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
Resource Type:: Dissertation
Full Text:: exchange mass spectrometry (HDX MS) technology for studying the conformational dynamics of large multi

Mass-spectrometric Methods for Quantitative Proteomics and Post-translational Modification Mapping

Creator:: Motorykin, Ievgen
Abstract:: Signal transduction within and between cells is at the core of biological activity in all living systems. Signaling networks are required for regulating biological functions, including growth, development and survival. Deregulation of signaling cascades has been linked to chronic and acute diseases and disorders This thesis focuses on mass spectrometry...
Resource Type:: Dissertation

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:: Madeen, Erin
Abstract:: The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...
Resource Type:: Dissertation
Full Text:: across genotypes. In addition, sensitive accelerator mass spectrometry (AMS) was

ScholarsArchive@OSU

Development and broad application of a mass spectrometry based metabolomics platform

The identification and quantitation of complex polycyclic aromatic hydrocarbon mixtures in environmental samples using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry

From fossils to phylogenies

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Spatiotemporal Phytohormone Distributions in Developing Pinot Noir Berries and the Effects of Two Viticulture Practices Thereon

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Mass-spectrometric Methods for Quantitative Proteomics and Post-translational Modification Mapping

Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

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