Index Catalog // ScholarsArchive@OSU

The Response to Sulforaphane in Metastatic Prostate Cancer Cells

Creator:: Watson, Gregory
Abstract:: Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
Resource Type:: Dissertation
Full Text:: . Chapter 3. Gregory Watson, Samanthi Wickramasekara, Yufeng Fang, Zoraya Palomera-Sanchez, Claudia S

SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells

Creator:: Watson, G. W., Wickramasekara, S., Palomera-Sanchez, Z., Black, C., Maier, C. S., Williams, D. E., Dashwood, R. H., and Ho, E.
Abstract:: The isothiocyanate sulforaphane is a promising molecule for development as a therapeutic agent for patients with metastatic prostate cancer. Sulforaphane induces apoptosis in advanced prostate cancer cells, slows disease progression in vivo and is well tolerated at pharmacological doses. However, the underlying mechanism(s) responsible for cancer suppression remain to be...
Resource Type:: Article

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:: Huang, Lin
Abstract:: Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
Resource Type:: Dissertation
Full Text:: Abstract approved: ______________________________________________________ Claudia S. Maier

Label-Free Proteomics Assisted by Affinity Enrichment for Elucidating the Chemical Reactivity of the Liver Mitochondrial Proteome toward Adduction by the Lipid Electrophile 4-hydroxy-2-nonenal (HNE)

Creator:: Tzeng, Shin-Cheng and Maier, Claudia S.
Abstract:: The analysis of oxidative stress-induced post-translational modifications remains challenging due to the chemical diversity of these modifications, the possibility of the presence of positional isomers and the low stoichiometry of the modified proteins present in a cell or tissue proteome. Alcoholic liver disease (ALD) is a multifactorial disease in which...
Resource Type:: Article
Full Text:: , USA *Correspondence: Claudia S. Maier claudia.maier@oregonstate.edu † Present Address: Shin-Cheng

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Creator:: Tzeng, Shin-Cheng
Abstract:: Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
Resource Type:: Dissertation
Full Text:: Model Abstract approved: Dr. Claudia S. Maier Alcoholic liver disease (ALD

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Creator:: Nirudodhi, Sasidhar N.
Abstract:: Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
Resource Type:: Dissertation
Full Text:: Conformational Dynamics in Large Protein Complexes Abstract approved: Claudia S. Maier Proteins are essential

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:: Yang, Liping
Abstract:: The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....
Resource Type:: Dissertation
Full Text:: : ______________________________________________________________ Dr. Claudia S. Maier

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Creator:: Zandkarimi, Fereshteh
Abstract:: State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Claudia S. Maier State-of-the-art, high-resolution mass spectrometry techniques for

Comparative analysis of the surface exposed proteome of two canine osteosarcoma cell lines and normal canine osteoblasts

Creator:: Milovancev, Milan, Hilgart-Martiszus, Ian, McNamara, Michael J., Goodall, Cheri P., Seguin, Bernard, Bracha, Shay, and Wickramasekara, Samanthi I.
Abstract:: Background: Osteosarcoma (OSA) is the most common primary bone tumor of dogs and carries a poor prognosis despite aggressive treatment. An improved understanding of the biology of OSA is critically needed to allow for development of novel diagnostic, prognostic, and therapeutic tools. The surface-exposed proteome (SEP) of a cancerous cell...
Resource Type:: Article
Full Text:: author(s) declare that they have no competing interests. Authors’ contributions All authors (MM, IHM

A Multiplex Biomarker Approach for the Diagnosis of Transitional Cell Carcinoma from Canine Urine

Creator:: Bracha, Shay, McNamara, Michael, Hilgart, Ian, Milovancev, Milan, Medlock, Jan, Goodall, Cheri, Wickramasekara, Samanthi, and Maier, Claudia S.
Abstract:: Transitional cell carcinoma (TCC), the most common cancer of the urinary bladder in dogs, is usually diagnosed at an advanced disease stage with limited response to chemotherapy. Commercial screening tests lack specificity and current diagnostic procedures are invasive. A proof of concept pilot project for analyzing the canine urinary proteome...
Resource Type:: Article

ScholarsArchive@OSU

The Response to Sulforaphane in Metastatic Prostate Cancer Cells

SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Label-Free Proteomics Assisted by Affinity Enrichment for Elucidating the Chemical Reactivity of the Liver Mitochondrial Proteome toward Adduction by the Lipid Electrophile 4-hydroxy-2-nonenal (HNE)

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Comparative analysis of the surface exposed proteome of two canine osteosarcoma cell lines and normal canine osteoblasts

A Multiplex Biomarker Approach for the Diagnosis of Transitional Cell Carcinoma from Canine Urine

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