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Filtering by: Creator Yin, HaiFang Decade 2010-2019

Fructose Promotes Uptake and Activity of Oligonucleotides With Different Chemistries in a Context-dependent Manner in mdx Mice

Creator:

Cao, Limin, Han, Gang, Lin, Caorui, Gu, Ben, Gao, Xianjun, Moulton, Hong M., Seow, Yiqi, and Yin, HaiFang

Abstract:

Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...

Resource Type:

Article
Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

Creator:

Yin, HaiFang, Boisguerin, Prisca, Moulton, Hong M., Betts, Corinne, Seow, Yiqi, Boutilier, Jordan, Wang, Qingsong, Walsh, Anthony, Lebleu, Bernard, and Wood, Matthew J. A.

Abstract:

We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of morpholino phosphorodiamidate oligomers (PMOs) in dystrophin-deficient mdx mice. In the present study, the general mechanistic significance of the...

Resource Type:

Article