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Filtering by: Committee Member Zabriskie, Mark T. Remove constraint Committee Member: Zabriskie, Mark T. Decade 2010-2019 Remove constraint Decade: 2010-2019

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  • Application of modern NMR techniques to structure elucidation of bioactive natural products from tunicates

    Creator:
    Sikorska, Justyna
    Abstract:
    Recent developments in NMR hardware have extended the reach of natural products chemists to structure elucidation of compounds isolated on a nanomolar scale. In parallel with advances in hardware new NMR techniques for structure elucidation have evolved, e.g. quantitative NOEs, residual dipolar couplings (RDCs)and diffusion-ordered spectroscopy (DOSY). The application of...
    Resource Type:
    Dissertation
    Full Text:
    my own projects. I also wish to acknowledge Dr. Philip J. Proteau and Dr. Mark Zabriskie for their

  • Biologically Active Secondary Metabolites from Red Sea Cyanobacteria

    Creator:
    Alhadab, Ali A.
    Abstract:
    This project describes the investigation of marine cyanobacteria collected from the Red Sea with an emphasis on the identification and prioritization of biologically active fractions for future purification and molecular structure elucidation of medicinally relevant secondary metabolites. Five crude extracts of taxonomically unidentified Red Sea cyanobacteria supplied by Egyptian collaborators...
    Resource Type:
    Honors College Thesis
    Full Text:
    Mark Zabriskie ALHADA01 Typewritten Text Christopher Thornburg ACKNOWLEDGMENTS First, I

  • Biosynthesis and Rational Design of Novel Pactamycin Analogs

    Creator:
    Abugrain, Mostafa E.
    Abstract:
    Pactamycin, a potent antitumor antibiotic produced by the soil bacterium Streptomycespactum, is a structurally unique aminocyclopentitol-containing natural product. Itconsists of a highly functionalized cyclopentitol core unit, two aromatic rings [3-aminoacetophenone (3AAP) and 6-methylsalicylic acid (6MSA)], and a 1,1-dimethylurea moiety. Despite its potent biological activity, the development of thisantibiotic was hampered...
    Resource Type:
    Dissertation
    Full Text:
    work. I would like to thank my committee members Dr. Barbara Taylor, Dr. Mark Zabriskie, Dr

  • Bioactive Microbial Natural Products from Unique Indonesian Black Water Ecosystems

    Creator:
    Sheng, Yan
    Abstract:
    The discovery of new antibiotics reached its peak during the golden era of antibiotics in the mid 20th century and continued to thrive until the 1980s. However, after more than 50 years of fruitful exploration and exploitation of microbial natural products the discovery rate of new antibiotics has dropped drastically...
    Resource Type:
    Dissertation
    Full Text:
    invaluable to me. I am so thankful to my advisory committee members Dr. Mark Zabriskie, Dr. Philip

  • Mechanistic Studies and Catalytic Engineering of the Pseudoglycosyltransferase VldE

    Creator:
    Abuelizz, Hatem A.
    Abstract:
    This thesis describes an investigation of the molecular basis of the substrate specificity and catalytic mechanism of a unique pseudoglycosyltransferase (PsGT) enzyme, VldE. PsGTs are a newly discovered group of glycosyltransferase (GT)-like proteins that catalyze the transfer of a pseudosugar to an acceptor molecule via a C-N bond formation. This...
    Resource Type:
    Dissertation
    Full Text:
    work. I also thank my thesis committee members Dr. Mark Zabriskie, Dr. Kerry McPhail, Dr. Fred

  • Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

    Creator:
    Vining, Oliver B.
    Abstract:
    Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
    Resource Type:
    Dissertation
    Full Text:
    also wish to thank Dr. Mark Zabriskie and Dr. Taifo Mahmud for their advice and support, as well as

  • Investigation of unique marine environments for microbial natural products

    Creator:
    Thornburg, Christopher C.
    Abstract:
    Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
    Resource Type:
    Dissertation
    Full Text:
    my very great appreciation to Dr. Mark Zabriskie for your kindness, support and advice throughout

  • Biosynthetic engineering of new pactamycins

    Creator:
    Lu, Wanli
    Abstract:
    Among the myriad of naturally occurring bioactive compounds are the aminocyclopentitol-containing natural products that represent a family of sugar-derived microbial secondary metabolites, such as the antibiotics pactamycin, allosamidin, and trehazolin. Pactamycin, a structurally unique aminocyclitol antibiotic isolated from Streptomyces pactum, consists of a 5-membered ring aminocyclitol (cyclopentitol) unit, two aromatic...
    Resource Type:
    Dissertation
    Full Text:
    . Mark Zabriskie, Dr. Arup Indra, Dr. Xihou Yin, and Dr. Kerry McPhail for their valuable time and

  • Development and testing of novel anti-tubercular drugs

    Creator:
    Almabruk, Khaled Husain G.
    Abstract:
    Tuberculoѕiѕ (TB) iѕ a number one killer among treatable infectious diseases. It is caused by the pathogenic bacterium Mycobacterium tuberculoѕiѕ that primarily affects the lungѕ. It infects one third of the world population and kills approximately 2 million people each year (based on WHO report). Drug-reѕiѕtant TB haѕ become a...
    Resource Type:
    Masters Thesis
    Full Text:
    . I would like to thank my graduate committee members, Dr. Mark Zabriskie, Dr. Jane Ishmael, Dr

  • Immobilization of Methylosinus trichosporium OB3b in a Biolamina Plate Reactor for the Oxidation of Methane to Methanol

    Creator:
    Fuchs, Brian K.
    Abstract:
    Methane is a flammable gas that is the main component of natural gas. It is a highly potent greenhouse gas, and accounts for about 20% of greenhouse gas emissions. Methane is routinely flared in many industrial processes without harnessing any of its energy. The environmental impact and wasted energy potential...
    Resource Type:
    Masters Thesis
    Full Text:
    experiments. Dr. Goran Jovanovic, Dr. Lew Semprini, and Dr. Mark Dolan all provided leadership on the