Index Catalog // ScholarsArchive@OSU

Analysis and Expansion of the Role of the Escherichia coli Protein ProQ

Creator:: Sheidy, Daniel T. and Zielke, Ryszard A.
Abstract:: The decrease in proline transport by the proline porter ProP in a Delta proQ strain has been well documented; however, the reason for this phenotype remains undefined. Previous studies have speculated that ProQ facilitates translation of proP mRNA. Here, we demonstrate that ProQ is enriched in the polysome fractions of...
Resource Type:: Article
Full Text:: Protein ProQ Daniel T. Sheidy1*, Ryszard A. Zielke2 1 Department of Molecular, Cellular, and

A Comparative Study of Chinese and American Musical Traditions

Creator:: Fine, Sarah
Abstract:: Music is a global tradition. Different cultures around the word have different musical traditions and histories, but all people create music for the same reason: the love of music and expressing oneself. In the spring of 2011, the Oregon State University Music Department entered into a cultural exchange program with...
Resource Type:: Honors College Thesis
Full Text:: : ____________________________________________________________ Steven Zielke Music is a global tradition. Different cultures around the word have

Targeting an Essential GTPase Obg for the Development of Broad-Spectrum Antibiotics

Creator:: Bonventre, Josephine A., Zielke, Ryszard A., Korotkov, Konstantin V., and Sikora, Aleksandra E.
Abstract:: A promising new drug target for the development of novel broad-spectrum antibiotics is the highly conserved small GTPase Obg (YhbZ, CgtA), a protein essential for the survival of all bacteria including Neisseria gonorrhoeae (GC). GC is the agent of gonorrhea, a prevalent sexually transmitted disease resulting in serious consequences on...
Resource Type:: Article
Full Text:: -Spectrum Antibiotics Josephine A. Bonventre1, Ryszard A. Zielke1, Konstantin V. Korotkov2, Aleksandra E

The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., and Sikora, Aleksandra E.
Abstract:: Background: Neisseria gonorrhoeae (GC) is a Gram-negative pathogen that most commonly infects mucosal surfaces, causing sexually transmitted urethritis in men and endocervicitis in women. Serious complications associated with these infections are frequent and include pelvic inflammatory disease, ectopic pregnancy, and infertility. The incidence of gonorrhea cases remains high globally while...
Resource Type:: Article

A Metalloprotease Secreted by the Type II Secretion System Links Vibrio cholerae with Collagen

Creator:: Park, Bo R., Zielke, Ryszard A., Wierzbicki, Igor H., Mitchell, Kristie C., Withey, Jeffrey H., and Sikora, Aleksandra E.
Abstract:: Vibrio cholerae is autochthonous to various aquatic niches and is the etiological agent of the life-threatening diarrheal disease cholera. The persistence of V. cholerae in natural habitats is a crucial factor in the epidemiology of cholera. In contrast to the well-studied V. cholerae-chitin connection, scarce information is available about the...
Resource Type:: Article

The Type II Secretion Pathway in Vibrio cholerae Is Characterized by Growth Phase-Dependent Expression of Exoprotein Genes and Is Positively Regulated by σ[superscript E]

Creator:: Zielke, Ryszard A., Simmons, Ryan S., Park, Bo R., Nonogaki, Mariko, Emerson, Sarah, and Sikora, Aleksandra E.
Abstract:: Vibrio cholerae, an etiological agent of cholera, circulates between aquatic reservoirs and the human gastrointestinal tract. The type II secretion (T2S) system plays a pivotal role in both stages of the lifestyle by exporting multiple proteins, including cholera toxin. Here, we studied the kinetics of expression of genes encoding the...
Resource Type:: Article

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Creator:: Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., Gafken, Philip R., Soge, Olusegun O., Holmes, King K., Jerse, Ann E., Unemo, Magnus, and Sikora, Aleksandra E.
Abstract:: Expanding efforts to develop preventive gonorrhea vaccines is critical because of the dire possibility of untreatable gonococcal infections. Reverse vaccinology, which includes genome and proteome mining, has proven very successful in the discovery of vaccine candidates against many pathogenic bacteria. However, progress with this approach for a gonorrhea vaccine remains...
Resource Type:: Article
Full Text:: Gonorrhea*□S Ryszard A. Zielke‡, Igor H. Wierzbicki‡, Benjamin I. Baarda‡, Philip R. Gafken§, Olusegun O

A Narrative Analysis of Captain America’s New Deal

Creator:: Ledbetter, Forest L.
Abstract:: In response to the events on September the Eleventh, various media attempted to make sense of the seemingly radical altered political landscape. Comic books, though traditionally framed as low brow pulp, were no exception. This thesis is a work of rhetorical criticism. It applies Walter Fisher's Narrative Paradigm to a...
Resource Type:: Masters Thesis
Full Text:: The comic book was a creation of the 1930’s it was a cross

Transkingdom network reveals bacterial players associated with cervical cancer gene expression program

Creator:: Lam, Khiem Chi, Vyshenska, Dariia, Hu, Jialu, Rodrigues, Richard Rosario, Nilsen, Anja, Zielke, Ryszard A., Brown, Nicholas Samuel, Aarnes, Eva-Katrine, Sikora, Aleksandra E., Shulzhenko, Natalia, Lyng, Heidi, and Morgun, Andrey
Abstract:: Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause the disease. Chromosomal amplifications have been identified as a source of upregulation for cervical cancer driver genes but cannot fully explain increased expression of immune genes in invasive carcinoma. Insight into...
Resource Type:: Article
Full Text:: . � Ryszard A. Zielke contributed reagents/materials/analysis tools, authored or reviewed drafts of the paper

The successful experiences of first generation community college transfer students

Creator:: McKenzie, René
Abstract:: The purpose of this qualitative phenomenological study was to explore the successes of first generation, community college transfer students served by a TRiO/Student Support Services (TRiO/SSS) program. This study addresses a specific problem in higher education – there are a limited number of first generation transfer students who successfully matriculate...
Resource Type:: Dissertation
Full Text:: explore the successes of first generation, community college transfer students served by a TRiO

ScholarsArchive@OSU

Analysis and Expansion of the Role of the Escherichia coli Protein ProQ

A Comparative Study of Chinese and American Musical Traditions

Targeting an Essential GTPase Obg for the Development of Broad-Spectrum Antibiotics

The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target

A Metalloprotease Secreted by the Type II Secretion System Links Vibrio cholerae with Collagen

The Type II Secretion Pathway in Vibrio cholerae Is Characterized by Growth Phase-Dependent Expression of Exoprotein Genes and Is Positively Regulated by σ[superscript E]

Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

A Narrative Analysis of Captain America’s New Deal

Transkingdom network reveals bacterial players associated with cervical cancer gene expression program

The successful experiences of first generation community college transfer students

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