Index Catalog // ScholarsArchive@OSU

Optimizing the Membrane Architecture and Interrogating the Stability of Hybrid Lipid-coated Gold Nanoparticles for Biological Studies and Applications

Creator:: Kmetz-Gonzalez, Gemma
Abstract:: Nanoparticles are a hugely diverse category of material that have a wide variety of biomedical applications, and developing tools for biological research with high cellular uptake is critical to their effective application. However, rarely is attention paid to the exact mechanism by which this is occurring, with most studies focusing...
Resource Type:: Capstone Project
Full Text:: changes in O.D., with 1 h changes for samples of 1:4 PC:Chol, SOA, HT 3.21 ± 0.13%. For comparison

Using Computational and Statistical Methods as an Aid to Study Environmentally Relevant Organic Molecules

Creator:: Dorn, Shelby E.
Abstract:: In this report, three studies are presented that utilize computations to predict transformations, identities, and properties of environmental organic molecules. Each study shows how computations can lead to models of chemical behavior. The importance of this research is rooted in the need for understanding how human behavior and health intersect...
Resource Type:: Masters Thesis
Full Text:: hydroxylated PAH intermediate, 3) computed atomic charges, and 4) average local ionization energy (ALIE

Structure-property Relationships of Transition Metal Oxides Containing Precious Metals

Creator:: Hapuraja Pathirannehelage, Vidhara H. P.
Abstract:: This dissertation presents a study of structure-property relationships within 3d/4d metal oxides containing precious metals through detailed structure refinements using high-resolution neutron and X-ray diffraction data along with exploration of the resultant properties. Oxides of 4d or 5d transition metals tend to show new topological phases due to significant spin-orbit...
Resource Type:: Dissertation
Full Text:: + or with 1/3 Li+ and 2/3 M 4+ in an octahedral environment of oxygen anions. According to literature

New Graphite Intercalation Chemistry with Alkaline Earth Metals

Creator:: Xu, Wei
Abstract:: Novel graphite intercalation compounds (GICs) and associated chemistry have been explored, specifically: (1) containing alkyl- substituted imidazolium cations; (2) a series containing alkaline earth metal (Mg, Ca, Sr, Ba) cations with ethylenediamine (en) co-intercalates; (3) showing reversible intragallery M-M bonding and (4) via electrochemical intercalation of Mg cations with potential...
Resource Type:: Dissertation
Full Text:: intragallery M-M bonding and (4) via electrochemical intercalation of Mg cations with potential application

Hydrophobicity, Anion Exchange, and Phytoaccumulation of Per- and Polyfluoroalkyl Substances (PFAS): Retention and Remediation

Creator:: Parker, Bethany A.
Abstract:: Per- and polyfluoroalkyl substances (PFAS) are a group of contaminants of great concern due to their toxicity and ubiquity in the environment. Remediation efforts historically have focused on granular activated carbon (GAC) because of its low maintenance and relatively low cost. However, GAC is not PFAS selective and is especially...
Resource Type:: Dissertation
Full Text:: and management 2011, 7 (4), 513-541. 2. Lindstrom, A. B.; Strynar, M. J.; Libelo, E. L

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Creator:: Points, Gary L., III
Abstract:: Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
Resource Type:: Dissertation
Full Text:: Christopher M. Beaudry Aromatic heterocycles are core structural motifs in natural products

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Creator:: Kim, GilSoo
Abstract:: The first part of this manuscript is about the total synthesis of the aspidosperma alkaloids leuconoxine, melodinine E and mersicarpine. Our synthetic strategy used a radical translocation-conjugate addition cascade to construct the core of the natural product. Specifically, a vinyl radical was generated from the homolysis of the C–I bond...
Resource Type:: Dissertation
Full Text:: , Phytochemistry 2003, 62, 1019 – 1025; c) M. Alberson, H. Orabi, T. F. Lue, Gerontology 2012, 58, 3 – 14. 3

Elucidating the Origins of Trends and Selectivities of Organic Reactions through Computations and Data Analysis Techniques

Creator:: Richardson, H. Camille
Abstract:: In this dissertation, a novel method for analyzing computed transition states (TS) for organic reactions is disclosed. It introduces the use of localization-delocalization matrices as parameters in a linear free energy relationship to determine the transition state interactions responsible for differences in energy between the major and minor TS in...
Resource Type:: Dissertation
Full Text:: -Lin Deng contributed to the computations. Paul H.-Y. Cheong, Darren W. Johnson, and Michael M. Haley

Insights and Patterns from Quantitative and Statistical Analyses of Chemical Systems

Creator:: Grove, Markas Albert
Abstract:: The work presented here is the culmination of efforts in describing complex chemical systems with statistical methods, thereby providing relatively simple quantitative models and easily comprehensible qualitative insights. The following investigations have various goals, such as development of new methods, fundamental understanding, molecular control of chemical species, and advancement of...
Resource Type:: Dissertation
Full Text:: . Nadarajah, A.;, Wu, Z. B.; Archila, K.; Kast, M. G.; Smith, A. M., Chiang, T. H.; Keszler, D. A.; Wager, J

Precursor-directed Biosynthesis and Total Synthesis of Aniline-containing Natural Products from the Endophytic Fungus Chalara sp. 6661

Creator:: Khoshbakht, Mahsa
Abstract:: Chalaniline A, an unusual xanthone-like aminofulvene with modest cytotoxicity, and chalaniline B [1-anilino-2,8-dihydroxy-3-(hydroxymethyl)xanthone], an antibacterial aminoxanthone, were previously isolated by Loesgen and coworkers from vorinostat-treated Chalara sp. 6661. Of note, the anilino moiety found within both chalaniline structures originates from biotransformation of the HDAC inhibitor vorinostat (SAHA, suberanilohydroxamic acid) by...
Resource Type:: Dissertation
Full Text:: formation with 19 different amines R1R2NH [XC6H4NH2: X = 3-F, 4-F, 4-Cl, 3-Br, 4-Br, 2-I, 3-OMe, 4-MeO, 3

ScholarsArchive@OSU

Optimizing the Membrane Architecture and Interrogating the Stability of Hybrid Lipid-coated Gold Nanoparticles for Biological Studies and Applications

Using Computational and Statistical Methods as an Aid to Study Environmentally Relevant Organic Molecules

Structure-property Relationships of Transition Metal Oxides Containing Precious Metals

New Graphite Intercalation Chemistry with Alkaline Earth Metals

Hydrophobicity, Anion Exchange, and Phytoaccumulation of Per- and Polyfluoroalkyl Substances (PFAS): Retention and Remediation

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

Elucidating the Origins of Trends and Selectivities of Organic Reactions through Computations and Data Analysis Techniques

Insights and Patterns from Quantitative and Statistical Analyses of Chemical Systems

Precursor-directed Biosynthesis and Total Synthesis of Aniline-containing Natural Products from the Endophytic Fungus Chalara sp. 6661

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