Search Constraints

Start Over
Filtering by: Creator Sukhatme, Gaurav S. Remove constraint Creator: Sukhatme, Gaurav S. Decade 2020-2029 Remove constraint Decade: 2020-2029 Resource Type Dissertation Remove constraint Resource Type: Dissertation

Search Results

  • Boosting Intracellular Delivery of mRNA Therapeutics

    Creator:
    Patel, Siddharth D.
    Abstract:
    Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Gaurav Sahay Abstract Intracellular delivery of mRNA holds great potential for vaccine

  • Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

    Creator:
    Kim, Jeonghwan
    Abstract:
    Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
    Resource Type:
    Dissertation
    Full Text:
    Therapeutics Abstract approved: ______________________________________________________ Gaurav

  • Non-viral Vectors for Ocular Gene Delivery

    Creator:
    Herrera-Barerra, Marco, F.
    Abstract:
    Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
    Resource Type:
    Dissertation
    Full Text:
    Gaurav Sahay ABSTRACT Nucleic acid therapeutics has cemented itself as one of the most

  • Learning to coordinate in sparse asymmetric multiagent systems

    Creator:
    Dixit, Gaurav
    Abstract:
    Multiagent learning offers a rich framework to address challenging real-world problems such as remote exploration and healthcare coordination, which require autonomous agents to express elaborate interactions. To be effective in such systems, agents must collectively reason about and pursue high-level, long-term, and possibly nebulous objectives while adapting their strategy to...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Gaurav Dixit for the

  • Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

    Creator:
    Sabei, Fahad Yahya
    Abstract:
    Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...
    Resource Type:
    Dissertation
    Full Text:
    would like to thank all of my committee members, Drs. Adam Alani, Gaurav Sahay, Jung Kwon for their

  • Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

    Creator:
    DuRoss, Allison N.
    Abstract:
    The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
    Resource Type:
    Dissertation
    Full Text:
    , Dr. Gaurav Sahay, and Dr. Jerry Jaboin, thank you for always attending meetings ready to provide

  • Transdermal Delivery of Atenolol to Cats

    Creator:
    Mohamed, Sumeia M.
    Abstract:
    This thesis describes in-vitro and in-vivo evaluation of a transdermal atenolol formulation developed at Oregon State University, College of Pharmacy. The formulation was prepared from carbomer as a gel base with propylene glycol, glycerol, ethanol, polysorbate 80 and dimethyl-isosorbide (DMI) as mixture of penetration enhancing agents. The effect of the...
    Resource Type:
    Dissertation
    Full Text:
    thesis committee: Dr Oleh Taratula, Dr. Gaurav Sahay and Dr. Sun Conroy for their encouragement

  • Fully-integrated mm-Wave Full-duplexing and MIMO Multi-beamforming Receiver Techniques for 5G and Beyond

    Creator:
    Garg, Robin
    Abstract:
    In recent years, the research community's interest in fully integrated mm-Wave wireless communication systems has increased significantly. With the standards for 5G NR now in place, the focus has shifted to actual deployment. Mm-Wave systems provide wider bandwidths, higher capacity, and lower latency than existing systems such as 4G. Higher...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: Arun S. Natarajan In recent years, the research community’s interest in fully

  • Mechanistic Properties of Plant-Soil Systems in Stormwater Treatment

    Creator:
    Hilliard, Richard
    Abstract:
    A dissertation describing the results of a series of greenhouse experiments conducted to better understand phytoremediation in stormwater bioretention systems.
    Resource Type:
    Dissertation
    Full Text:
    †, Staci Massey Simonich† §, Jennifer Field§, Tyler S. Radniecki‡ * † Department of Chemistry

  • Characterizing and Addressing Dataset Shift with Deep Learning

    Creator:
    Olson, Matthew L.
    Abstract:
    This dissertation delves into understanding, characterizing, and addressing dataset shift in deep learning, a pervasive issue for deployed machine learning systems. Integral aspects of the problem are examined: We start with the use of counterfactual explanations in order to characterize the behavior of deep reinforcement learning agents in visual input...
    Resource Type:
    Dissertation
    Full Text:
    deviations (± std) for each case, and “G. S” refers to the greedy strategy that we use for alignment