Index Catalog // ScholarsArchive@OSU

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Creator:: Rauenhorst, Jacob
Abstract:: With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Resource Type:: Honors College Thesis
Full Text:: /d0md00196a. (39) Marquez Loza, A.; Elias, V.; Wong, C. P.; Ho, E.; Bermudez, M.; Magnusson, K. R. Effects of

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Creator:: Sackinger, Emily P.
Abstract:: Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: ______________________________________________________ Kathy R. Magnusson

Effects of age and military service on memory and cognitive flexibility in a virtual Morris water maze task

Creator:: Mollusky, Adina J.
Abstract:: This study applied a virtual version of the Morris water maze (vMWM) task to an examination of age-related differences between younger and older participants, and the impact of prior military service in older men on spatial memory and cognitive flexibility. Participants performed the Logical Memory task that included immediate and...
Resource Type:: Honors College Thesis
Full Text:: Kathy Magnusson This study applied a virtual version of the Morris water maze (vMWM) task to an

The Role of Nrf2 in Brain Cellular Senescence

Creator:: Ross, Grace K.
Abstract:: Aging is a major risk factor for the deterioration of biochemical pathways that lead to many chronic neurodegenerative disorders (i.e. Parkinson’s and Alzheimer's Disease). Cellular senescence is a hallmark of aging, a condition characterized by stable growth arrest resulting in a cell that no longer divides, but is metabolically active....
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Biomedical Sciences, College of Veterinary

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Creator:: Ewton, Jessica
Abstract:: Gonadotropin-releasing hormone (GnRH) neurons are able to trigger the release of luteinizing hormone and follicle-stimulating hormone which control the maturation of oocytes and ovulation which is vital for reproduction. They are the most downstream neurons that project to the median eminence into the pituitary portal where they release GnRH. Modulation...
Resource Type:: Honors College Thesis
Full Text:: Biomedical Sciences Jennifer Johns, Committee Member, representing Clinical Pathology Kathy Magnusson

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

Creator:: Rayzman, Noa
Abstract:: Estradiol (E2) plays a role in positive and negative feedback mechanisms of the hypothalamic-pituitary-gonadal (HPG) axis in female mammals. These mechanisms are regulated by two different populations of kisspeptin (KP)-producing neurons: anteroventral periventricular (AVPV) neurons, which are stimulated by E2, and arcuate (arc) neurons, which are inhibited by E2. AVPV...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Kathy Magnusson, Committee Member, representing Neuroscience

Investigating the Interplay of Age, Zinc Status, and the Gut Microbiome on Gut Health

Creator:: Vasudevan, Anusha
Abstract:: Zinc is an important micronutrient involved in many cellular processes, including those part of immune function; however, about 15% of the US population is at risk for marginal zinc deficiency. This can lead to immune system complications including the generation of inflammatory cytokines. Aging is another factor that worsens the...
Resource Type:: Honors College Thesis
Full Text:: 2014, 1, 14. https://doi.org/10.3389/fnut.2014.00014. 3. Wong, C. P.; Magnusson, K. R.; Sharpton

Low-Dose X-Ray Radiation Effects On the Proteomic Profiles of Hippocampus, Cortex, and Cerebellum of Contextual Fear Conditioning and Novel Object Recognition Trained Mice

Creator:: Koluda, Rony
Abstract:: Radiation exposure to the brain can occur from a variety of events, including space missions, nuclear accidents, and clinical treatments. The effects of high dose radiation are well studied, but those of lower dosage are more elusive. Decline of memory and cognition is observed in patients exposed to low dose...
Resource Type:: Masters Thesis
Full Text:: , and Dr. Kathy Magnusson, for their unwavering support in the completion of my degree despite the

Investigating the Impact of the Gut Microbiota on Rodent Behavior and their Interaction with Enteroendocrine Cells

Creator:: Singla, Priyanka
Abstract:: Gut-brain communication consists of bidirectional routes between cognitive centers of the brain and peripheral intestines. This bidirectional communication is the result of the interplay between enteroendocrine cells (EECs), enteric nervous system, central nervous system, the vagus nerve, and our microbiota. Multiple studies have associated gut microbial dysbiosis with neurological disorders...
Resource Type:: Masters Thesis
Full Text:: for this project, and Prof. Kathy Magnusson for helping us with the nodose ganglion dissection. Also

The Effect of Zinc Status and Age on Liver Health in Mice

Creator:: Braun, Kendra N.
Abstract:: Age-related diseases have been associated with chronic inflammation and impaired immune response, one of the hallmarks of aging. Aging individuals also have a higher susceptibility to zinc deficiency. The effects of zinc deficiency share many commonalities with the effects of aging on the immune system and zinc deficiency may be...
Resource Type:: Honors College Thesis
Full Text:: . Mol Nutr Food Res, 56(1), 77–87. https://doi.org/10.1002/mnfr.201100511 Wong, C. P., Magnusson, K. R

ScholarsArchive@OSU

Ibuprofen Treatment Causes NMDA and AMPA Receptor Hyperactivity in Female Wild Type and Heterozygous 5xFAD mice but not Males

Cannabidiol Effects on NMDA and AMPA Receptor Activity and Cognitive Function at a High Dose in 5xFAD Mice

Effects of age and military service on memory and cognitive flexibility in a virtual Morris water maze task

The Role of Nrf2 in Brain Cellular Senescence

The analysis of kisspeptin neuronal exosomes and their effects on neuronal plasticity of downstream gonadotropin-releasing hormone expressing neurons

Expression of Gonadotropin-Releasing Hormone Receptor in Kisspeptin Neurons: A Potential Model For Positive Feedback

Investigating the Interplay of Age, Zinc Status, and the Gut Microbiome on Gut Health

Low-Dose X-Ray Radiation Effects On the Proteomic Profiles of Hippocampus, Cortex, and Cerebellum of Contextual Fear Conditioning and Novel Object Recognition Trained Mice

Investigating the Impact of the Gut Microbiota on Rodent Behavior and their Interaction with Enteroendocrine Cells

The Effect of Zinc Status and Age on Liver Health in Mice

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