Estrogen is a sex hormone responsible for the development and regulation of the reproductive system and secondary sex characteristics. They also play a critical role in the development of breast and uterine cancer. The formation of agonistic metabolites of estrogen, especially 16α-hydroxyestrone, have been found to have cancer-inducing effects meanwhile...
Developers frequently change the type of a program element and update all its references for performance, security, concurrency, library migration, or better maintainability. Despite type changes being a common program transformation, it is the least automated and the least studied. Manually performing type changes is tedious since the programmers have...
Merge conflicts have long plagued software development. With larger and more dispersed teams comes greater risk of developers working on the same code at the same time. While merge conflicts are known to be painful, their exact impact on software is still largely unknown. Are merge conflicts an isolated problem,...
Enabled by a rich ecosystem of Machine Learning (ML) libraries, programming using learned models, i.e., Software-2.0, has gained substantial adoption. However, we do not know what challenges developers encounter when they use ML libraries. With this knowledge gap, researchers miss opportunities to contribute to new research directions, tool builders do...
Recently, Explicit Congestion Notification (ECN) has been leveraged by most Datacenter Network (DCN) protocols for congestion control to achieve high throughput and low latency. However, the majority of these approaches assume that each switch port has one queue while current industry trends towards having multiple queues per switch port. To...
Back pain is the leading cause of disability worldwide, entailing a significant socioeconomic impact. A primary source of back pain can be attributed to intervertebral disc (IVD) degeneration allowing nerve ingrowth, facet joint arthritis, disc bulging, and osteophyte formations that press on nearby nerve roots or the spinal cord. While...
Distributed version control allows developers to manage software evolution among distributed development teams. But it does not eliminate all consistency and concurrency issues, and instead introduces additional complexity when merging code. And resolving merge conflicts is nontrivial when automated merging fails. In such cases, developers are forced to inspect the...
The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...
Microbial communities in Arctic coastal lagoons drive biogeochemical cycles at the terrestrial-marine interface and help to determine the fate and form of resources like nitrogen (N) and carbon (C) as they are delivered to the Arctic Ocean. Though rising rates of primary production in the Arctic Ocean are well-characterized, the...
Civil engineers are aware of the impacts of structures on the global environment but the environmental impacts of a fire within these structures remains unknown. Fires present a unique hazard as it is difficult to predict the probability of the occurrence and the intensity. Traditional methods to identify the environmental...
We consider three problems on simplicial complexes: the Optimal Bounded Chain Problem, the Optimal Homologous Chain Problem, and 2-Dim-Bounded-Surface. The Optimal Bounded Chain Problem asks to find the minimum weight d-chain in a simplicial complex K bounded by a given (d−1)-chain, if such a d-chain exists. The Optimal Homologous Chain...
Concrete has been categorized as a key contributor of CO2 (carbon) emissions into the atmosphere. This is mostly associated with the production of ordinary portland cement (OPC). The concrete and cement industries are pursuing a path to reduce their carbon emissions generally in accordance with the climate change goals outlined...
This thesis primarily investigates nonhumans in the writings of 12th century historians. Where these writings may typically be seen as having little room for nonhuman agency, this thesis investigates how divinity, as an important part of medieval life, creates a space for nonhuman agency that is otherwise overlooked. In chapter...
Drosophila suzukii (Diptera: Drosophilidae) is an insect of global concern that causes serious damage to soft-skinned fruits. D. suzukii is widespread in North America, South America, Europe, and Asia and is listed as an invasive pest with strict quarantine protocols governing import and export. Given the damage caused by D....
Social robots benefit from a sense of humor, which requires the ability to recognize and adapt to human responses during playful interactions. Past work on humorous robots has classified audience responses with audio-based and preliminary visual-based methods following the joke punchline. Building on this progress, we conducted a survey of...
Mental health among student athletes has gotten much more attention in the world of sport today. However, there has been a lack of research focusing on how the socioeconomic backgrounds of Division 1 student athletes can play a role in their mental health and their desire to seek out help...
Software systems are becoming an essential part of the lives of both individuals and organizations, and as a consequence, these systems are getting bigger and more complex. Because of this, the tasks of maintaining the quality in these complex software systems are becoming increasingly difficult. Furthermore, these systems are subject...
Autonomous robotic agents are on their way to becoming in-home personal assistants, construction assistants, and warehouse workers. The degree of autonomy of such systems is reflected by the manner in which we specify goals to them; the abstraction of low-level commands to high-level goals goes hand-in-hand with increased autonomy. In...
The azalea lace bug (Stephanitis pyrioides Scott) is a global pest of rhododendrons and azaleas (Rhododendron spp.). It is originally from Asia, has been established in the eastern U.S. for the past century, and was recently detected in the Pacific Northwest in 2008-2009. Stephanitis pyrioides feeds on the underside of...
Drosophila suzukii (Diptera: Drosophilidae), is a serious pest in soft and stone fruit industries worldwide. The unique serrated ovipositor of female Drosophila suzukii allowed the species to reproduce in intact, ripening fruit before the harvest. Current control methods rely heavily on insecticide application, only becoming less profitable due to the...
In this dissertation, I investigate the evolution and genomes of carabid beetles, a worldwide family of over 38,000 species. I focus on two species-rich groups, the tribes Chlaeniini and Bembidiini, both of which are primarily found on the shores of bodies of water. The former are distinctive for their defensive...
Iterative algorithms are simple yet efficient in solving large-scale optimization problems in practice. With a surge in the amount of data in past decades, these methods have become increasingly important in many application areas including matrix/tensor recovery, deep learning, data mining, and reinforcement learning. To optimize or improve iterative algorithms,...
The ferromagnetic resonance (FMR) phenomenon serves as a sensitive probe of the effective internal fields in a magnetic material. FMR spectroscopy has consequently become a well-established technique, extensively employed in assessing material properties such as magnetic anisotropy, Landé g-factor, damping parameter, and the magnetoelastic constants of magnetic materials. Determining these...
The climate of the Pacific Northwest is in flux, and existing forest ecosystems are stressed and poised to shift in fundamental ways, with or without human intervention. This dissertation probes the nature of forest responses to environmental change through investigations of morphology and genetics of three species of alder co-occurring...
With growing interest in mass timber, especially mass timber panels (MTP), there has been a need to better understand their structural properties. One of the most versatile uses for MTP are as floor systems. Under new code provisions, these floors can be utilized in new and taller building types, but...
(Polycyclic aromatic hydrocarbons) PAHs are widespread in the environment, and are derived from both natural and anthropogenic sources. The physicochemical properties of PAHs along with the wide range of PAH sources leads to their persistence in the environment. Since PAHs are ubiquitous, and have the potential to illicit adverse effects,...
The issue of chloride-induced corrosion of reinforcing steel in concrete and its economic impacts are well-known. Chlorides that cause reinforcement corrosion can be from constituent materials used to prepare concrete or can enter the hardened concrete when the structure is exposed to chloride environments. To minimize the risk of reinforcement...
Biologists have long been fascinated with reproductive traits, in part because they are frequently exaggerated or showy, and they commonly vary among closely related species. Exaggerated sexual traits, in particular, have been the focus of intense empirical and theoretical research, but most of this work has focused on traits involved...