Among the myriad of natural products are pseudosugar-containing secondary metabolites, e.g., the C7-pseudosugar-containing oligosaccharide acarbose, the C6- pseudosugar-containing aminoglycoside antibiotics, and the five-membered ring pseudosugar-containing antibiotic pactamycin. The C7-pseudosugars are normally derived from sedoheptulose 7-phosphate catalyzed by a family of enzymes called sedoheptulose 7-phosphate cyclases (SH7PCs). This family of enzymes...
The 180,000 km² of Arabian lava fields (“harrats” in Arabic) form one of the largest distributed basaltic provinces in the world. Approximately 50% of these are located in Saudi Arabia. The most recent eruption in 1256 AD, as well as seismicity and ground deformation associated with shallow dike emplacement in...
The Klamath River Basin (KRB) is one of the most contested basins of the Western U.S. with respect to water. Multiple stakeholders, including Tribes, farmers, state and federal agencies, and environmental advocates, are in frequent conflict over water rights and water use. Removal of the four hydroelectric dams is one...
Continuous Improvement (CI) of academic computing programs is a main requirement of accreditation. Academic computing programs must have a well-documented CI plan in order to be granted accreditation. Based on the existing literature, we developed a comprehensive CI (or 360-CI) model consisting of 8 components: course, curriculum, administration, faculty, research,...
The knowledge about the intensive agricultural irrigation is very limited, but the use of irrigation is rapidly increasing. As an outcome, the sympathetic ecosystem is accepting modern irrigation that will play an essential function in the present and future for agricultural products. My dissertation will display the modification for investigation...
Otoferlin is a protein that is essential in the process of hearing. Mutations in otoferlin are associated with profound recessive deafness. The long-term goal of the Johnson lab is to understand how otoferlin contributes to hearing and why certain mutations result in deafness. This project sought to characterize the difference...
Public housing (PH) provides a substantial portion of the housing in both developed and less developed countries, and the demand for it is increasing. The PH projects, however, are facing many challenges that are affecting their performance and cause their failures. The United States has demolished large portions of their...
Salt-encrusted flats, or Sabkha, are common in arid and semi-arid regions worldwide, including coastal and inland areas. Due to their low shear strength and high compressibility, these soils are often unsuitable for supporting infrastructure or structures. The unique salt content of sabkha formations sets them apart from other soil types....
Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...