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Filtering by: Advisor Blakemore, Paul Remove constraint Advisor: Blakemore, Paul Decade 2020-2029 Remove constraint Decade: 2020-2029

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  • Stereocontrolled Synthesis of Allenes by Eliminative Cross-Coupling of Carbenoids

    Creator:
    Cao, Yang
    Abstract:
    The bimolecular reaction of two carbenoid species resulting in the formation of a carbon-carbon double bond (pi-system), referred to herein as carbenoid eliminative cross-coupling (CEXC), involves a series of three fundamental steps: (i) ate-complex formation (transmetalation), (ii) 1,2-metalate rearrangement, and (iii) beta-elimination. All three steps are stereospecific and so the...
    Resource Type:
    Dissertation
    Full Text:
    Paul R. Blakemore The bimolecular reaction of two carbenoid species resulting in the formation

  • Precursor-directed Biosynthesis and Total Synthesis of Aniline-containing Natural Products from the Endophytic Fungus Chalara sp. 6661

    Creator:
    Khoshbakht, Mahsa
    Abstract:
    Chalaniline A, an unusual xanthone-like aminofulvene with modest cytotoxicity, and chalaniline B [1-anilino-2,8-dihydroxy-3-(hydroxymethyl)xanthone], an antibacterial aminoxanthone, were previously isolated by Loesgen and coworkers from vorinostat-treated Chalara sp. 6661. Of note, the anilino moiety found within both chalaniline structures originates from biotransformation of the HDAC inhibitor vorinostat (SAHA, suberanilohydroxamic acid) by...
    Resource Type:
    Dissertation
    Full Text:
    Endophytic Fungus Chalara sp. 6661 Abstract approved: Paul R. Blakemore Chalaniline A, an

  • Total Synthesis of Isotopologues of Xanthohumol and its Congeners for Biological Studies

    Creator:
    Plagmann, Layhna S.
    Abstract:
    Xanthohumol [XN, (E)-6´-methoxy-3´-(3-methylbuten-2-yl)-2´,4´,4´´-trihydroxychalcone], the principal prenylated chalcone from hops, and its 2,3-dihydro- (DXN) and O6-desmethyl-2,3-dihydro- (DDXN) congeners, are of potential utility for the amelioration of metabolic syndrome; however, their complex bioactivity profiles cannot be properly studied and understood without access to appropriately produced synthetic materials. In the first part of...
    Resource Type:
    Masters Thesis
    Full Text:
    expresses sincere appreciation to the following people: Prof. Paul R. Blakemore, for his outstanding

  • Development of Carbenoid Eliminative Cross-coupling for the Stereocontrolled Synthesis of Trisubstituted Alkenyl Moieties Within Styrenes and 1,3-Dienes

    Creator:
    Tanpure, Subhash D.
    Abstract:
    Traditional approaches for the direct preparation of alkenes are unable to fully control either the stereochemical configuration of the carbon-carbon double bond or else the regiochemistry of the substituents surrounding it. The recently introduced concept of carbenoid eliminative cross-coupling (CEXC) offers a remedy to these deficiencies by providing for a...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________ Paul R. Blakemore Traditional approaches for the direct preparation of alkenes are