Obesity and metabolic syndrome (MetS) affect over 1.9 billion adults and 12.7 million youth in the US. If all of today’s obese American youth become obese adults, the total societal costs over their lifetime may exceed $1.1 trillion. We show that feeding rodents a high-fat diet supplemented with xanthohumol (XN)...
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AdrianF. Gombart
Obesity and metabolic syndrome (MetS) affect over 1.9 billion adults and
Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Vitamin E (vitE) is a group of lipid-soluble antioxidants- of which alpha-tocopherol is the most biologically active and only form considered to be an essential nutrient. Through preferential binding and trafficking, the alpha-tocopherol transfer protein (α-TTP) regulates the concentration of vitE in the body. The impact of vitE deficiency on...
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AdrianGombart, Committee Member, representing Department of Biochemistry and Biophysics
Brewers' spent grain (BSG), the byproduct from beermaking, is a good source of protein and dietary fiber and may be utilized as a functional ingredient for food applications such as bakery goods. Starch-based film is well-known for its safety, edibility, and renewability. Starch films with the incorporation of cellulose nanofiber...
Fiction facilitates the attribution of unrealistic character traits to scientists, and skews general understanding of the scientific process-- a fatal flaw resulting in self-doubt within undergraduate scientists, and apprehension and distrust in several communities. Misconceptions and the absence of significant ideas were identified by analyzing novels within the “Lab Lit”...
Agricultural and companion animals are integral to our way of life as they provide us with nourishment, financial resources, transportation, and companionship. However, pets, managed animals in the agricultural industry, as well as wild populations of food animals are all subject to health and mortality risks. The gut microbiome is...
Soils contain the largest pool of carbon that is actively cycling on human timescales, leading many to view soils as a natural climate solution with multiple co-benefits. The field of soil science is rapidly evolving, but without a unified understanding of soil carbon dynamics. This dissertation leverages two distinct long-term...
Streptococcus pneumoniae and Influenza A Virus both primarily infect the upper respiratory tract, with more severe disease occurring during coinfection than would be caused by either pathogen independently. Until recently, characterization of the interactions between these two pathogens has occurred exclusively in the context of a host or using host-derived...
The design of a competition-winning aero package must consider multiple vehicle attitudes. Aerodynamic concepts simulated in heave, pitch, roll, high-speed yaw, and low-speed yaw to design a stable and predictable aero package. The methodology automates the simulation setup process of five vehicle attitudes. The overall and subsystem force coefficients are...
Metal Organic Framework Structures (MOFs) have shown great promise for use in gas storage. Computer simulations have been touted as a method to identify strong candidate molecules for experimental research. This project assessed the relationship between computer simulations of methane absorption and experimental gas absorption. We acquired experimental data and...