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Filtering by: Committee Member Ho, P. Shing Decade 2020-2029

Identifying Differences in the Release of Bioactive Milk Peptides Across the Intestinal Tract Between Term and Preterm Infants

Creator:

Beverly, Robert L.

Abstract:

Premature birth interrupts the typical development of the human fetus, leaving the infant born with underdeveloped gastrointestinal and immune systems. Preterm infants have reduced stomach acidity, reduced digestive protease activity, more permeable intestinal membranes, impaired innate and adaptive immune response, and poor microbiome development. Due to these factors, preterm infants...

Resource Type:

Dissertation

Full Text:

research and neonatal care. I expressly thank my committee members–Dr. Donald Jump, Dr. Emily Ho, Dr
From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

Creator:

Meeuwsen, Joseph C.

Abstract:

Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...

Resource Type:

Dissertation

Full Text:

, role modeling, and assistance. To my committee members – Drs. Emily Ho, Andy Karplus, Kathy