This dissertation delves into understanding, characterizing, and addressing dataset shift in deep learning, a pervasive issue for deployed machine learning systems. Integral aspects of the problem are examined: We start with the use of counterfactual explanations in order to characterize the behavior of deep reinforcement learning agents in visual input...
Dimensional stability of wood-based composites with changing moisture content remains an important challenge in the industry for many applications. Wood modification technologies have shown significant improvement in dimensional stability by altering the chemistry of the wood substrate, or by filling the available space in the wood microstructure that otherwise would...
The immune system is a complex network of cellular processes working in harmony to guard us against pathogenic attack. Of utmost importance is the ability of the immune system to discriminate between “self” and “non-self” and diseased versus healthy. Recognition of antigens complexed to major histocompatibility complex (MHC) molecules is...
The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
Observed declines in native pollinator species worldwide has generated concern and focused research into the disturbances, past and present, which may have contributed to these losses. In grasslands, for example, habitat degradation and fragmentation from historical and current crop production and livestock grazing has left only a few remnants of...
The gut microbiome has been previously implemented in a number of diseases. Of note is its substantial role in metabolic syndrome, which encapsulates a group of conditions that increase the risk of cardiovascular disease, type 2 diabetes, and stroke. Understanding the causal relationships between the gut microbiome and host processes...
Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
In high volume automated discrete item batch production systems, the batches or lots are typically fixed quantity (i.e., size), with setups incurred between the different production lots. Processing times for the fixed-size lots are relatively constant when the workstation is operating however, random workstation disruptions cause variability in the lot...
Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
Top-performing approaches to embodied AI tasks like point-goal navigation often rely on training agents via reinforcement learning over tens of millions (or even billions) of experiential steps – learning neural agents that map directly from visual observations to actions. In this work, we question whether these extreme training durations are...