Index Catalog // ScholarsArchive@OSU

Nucleic Acid Based Therapeutics for Treatment of Cystic Fibrosis

Creator:: McKinney, Madison J.
Abstract:: Cystic fibrosis is an inherited genetic disease caused by a single gene mutation in the CFTR protein. Affecting 70,000 people worldwide, this disease is debilitating to patients, resulting in persistent lung infections and decreased quality of life. Due to the various mutation types, there is not currently a single drug...
Resource Type:: Honors College Thesis
Full Text:: Nucleic Acid Based Therapeutics for Treatment of Cystic

Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Creator:: Kim, Jeonghwan
Abstract:: Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
Resource Type:: Dissertation
Full Text:: acids from nucleases, (2) controlled release of nucleic acid, (3) cell and tissue selectivity, (4

Importance of TLR2 and TLR4 signaling against M. abscessus infection of macrophages and use of mycobacteriophage genomics toward understanding some of the aspects of phage therapy

Creator:: Kapoor, Hannah A.
Abstract:: Mycobacterium abscessus (MAB) is an opportunistic pathogen responsible for infections in immunocompromised or immunosuppressed patients. Even with long-term treatment with multiple antibiotics, MAB pulmonary infections have high rates of treatment failure. Within the host, MAB is phagocytosed by key innate immune cells macrophages. The TLR2 and TLR4 are two critical...
Resource Type:: Honors College Thesis
Full Text:: some of the aspects of phage therapy by Hannah Kapoor A THESIS submitted to Oregon State

Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

Creator:: DuRoss, Allison N.
Abstract:: The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
Resource Type:: Dissertation
Full Text:: radiation therapy. In addition to radioenhancing nanoparticles, there are drug-carrying nanoparticles that

Development of Rapid Diagnostic Tools for Personal Health Monitors in the Context of Therapy Monitoring

Creator:: Wentland, Lael T.
Abstract:: Personal health monitoring tools, a subset of point-of care-diagnostics, enable more frequent testing of chronic health conditions outside of a clinic setting and can inform personalized therapy or support telehealth diagnostic capabilities. While there is evidence that regular monitoring of chronic conditions can lead to better health outcomes and lower...
Resource Type:: Dissertation
Full Text:: cost per test. The MAD NAAT (Multiplex-able autonomous disposable nucleic acid amplification test) is

Integration of Amino Acid Sequence and Alphafold2 Structural Predictions for Chlamydia trachomatis Polymorphic Membrane Proteins

Creator:: DeBrine, Abigail
Abstract:: Chlamydia trachomatis is an obligate intracellular bacterium that causes diseases of the eye and urogenital tract in humans. It is the cause of the sexual transmitted infection (STI) chlamydia, the most prevalent STI worldwide, and the ocular disease trachoma, the leading cause of infectious blindness. To date there is no...
Resource Type:: Honors College Thesis
Full Text:: States as Determined by the Aptima Trichomonas Vaginalis Nucleic Acid Amplification Assay. J Clin

Precision Medicine for the Intervertebral Disc: Image Processing and Computational Modeling of Disc Degeneration to Inform Patient-Specific Therapies

Creator:: Ahrens, Sonia R.
Abstract:: The human intervertebral disc is a deceptively simple structure which plays an essential role in human movement. Even slight changes to the disc microenvironment can have far reaching consequences, particularly when these changes result in disc degeneration and herniation. Degeneration is increasingly tied to lower back pain; better understanding this...
Resource Type:: Masters Thesis
Full Text:: glucose, lactic acid and oxygen distribution within the disc for Patient #1……………………………………………………………………. 24

Tuning tRNA and EF-Tu for the Efficient Site-specific Incorporation of Noncanonical Amino Acids into Proteins

Creator:: Gottfried-Lee, Ilana L.
Abstract:: Genetic code expansion (GCE) is a technology that allows us to incorporate noncanonical amino acids (ncAAs) site-specifically into recombinant proteins using engineered translational machinery. Typically, an orthogonal aaRS/tRNA pair is engineered by directed evolution to recognize the ncAA and incorporate it at a reassigned codon while not interacting with the...
Resource Type:: Honors College Thesis
Full Text:: -specific Incorporation of Noncanonical Amino Acids into Proteins by Ilana Gottfried-Lee

An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

Creator:: Manchanda, Aayushi
Abstract:: Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
Resource Type:: Dissertation
Full Text:: for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented on October 22

Vitamin E Protects Developmental Gene Expression and Metabolic Networks in Zebrafish Embryos

Creator:: Head, Brian A.
Abstract:: Vitamin E (VitE) is necessary for vertebrate embryonic development. VitE prevents lipid peroxidation (LPO), which requires detoxification by cellular antioxidant systems subsequently involving reducing power derived from energy metabolism. Thus, VitE protects metabolic networks in the developing embryo and the integrated gene expression networks compensating for and impaired by LPO-induced...
Resource Type:: Dissertation
Full Text:: polyunsaturated fatty acids (PUFA), especially docosahexaenoic acid (DHA) [11] in cell membrane PUFA-rich lipid

ScholarsArchive@OSU

Nucleic Acid Based Therapeutics for Treatment of Cystic Fibrosis

Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

Importance of TLR2 and TLR4 signaling against M. abscessus infection of macrophages and use of mycobacteriophage genomics toward understanding some of the aspects of phage therapy

Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

Development of Rapid Diagnostic Tools for Personal Health Monitors in the Context of Therapy Monitoring

Integration of Amino Acid Sequence and Alphafold2 Structural Predictions for Chlamydia trachomatis Polymorphic Membrane Proteins

Precision Medicine for the Intervertebral Disc: Image Processing and Computational Modeling of Disc Degeneration to Inform Patient-Specific Therapies

Tuning tRNA and EF-Tu for the Efficient Site-specific Incorporation of Noncanonical Amino Acids into Proteins

An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

Vitamin E Protects Developmental Gene Expression and Metabolic Networks in Zebrafish Embryos

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