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Filtering by: Date 2006 Subject Colon (Anatomy) -- Cancer -- Genetic aspects

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

Creator:

Smith-Roe, Stephanie L.

Abstract:

The DNA mismatch repair (MMR) pathway maintains genomic stability and reduces cancer risk (colorectal and other internal cancers) by correcting polymerase errors and activating cell cycle checkpoints and apoptosis in response to DNA damage. Few studies have examined the influence of commonly encountered environmental mutagens/carcinogens on the etiology of MMR-deficient...

Resource Type:

Dissertation
Functional analysis of the pathogenic mutation MLH1-E578G on human MLH1 activity in DNA mismatch repair

Creator:

Huo, Xin

Abstract:

Mismatch repair (MMR) system performs mainly three roles to maintain genomic stability, correct DNA biosynthetic errors, ensure the fidelity of genetic recombination, and in mammalian cells participate in the cellular response to some DNA damages. Deficiencies in mismatch repair increase mutation rates and cancer risks. In eukaryotes, the MMR system...

Resource Type:

Masters Thesis
Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

Creator:

O'Donnell, Edmond Francis

Abstract:

DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...

Resource Type:

Honors College Thesis