This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Seasonal wetlands in arid and semi-arid lands provide an important source of surface water in otherwise dry lands. Central Oregon's high desert, located in the Northern Great Basin (NGB) is dotted with hundreds of seasonal pools, locally called playas. The playas hold water or snow during parts of winter and...
This thesis presents an approach to develop innovative methods for decontamination and surface protection applicable to naval nuclear ships and potentially, personnel, replacing antiquated techniques. To accomplish this goal, two products manufactured by CBI Polymers, LLC., DeconGel™ 1101 (1101) and a shampoo, DeconGel™ "prototype" (prototype), were tested.
The prototype was...
This thesis is comprised of two manuscripts based on a laboratory experiment conducted to examine realistic wave forcing on a vertical wall subjected to tsunami loading. The first manuscript examined tsunami force and pressure distributions on a rigid wall that was fronted by a small seawall. Six different seawall heights...
The overall goal of this project was to design a wood frame shear wall that could withstand greater displacement before damage occurred to the Gypsum Wall Board (GWB). More specifically, the objectives of the study were: (1) to evaluate damage to the GWB in alternative shear wall designs at 1%,...
Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
Stripe rust (Puccinia striiformis f. sp. tritici) has been receiving
increased attention in the USA since the appearance of more virulent races
detected in the past decade. These races caused yield losses even in areas
where the disease previously was rarely detected. Host plant resistance is the
most cost effective...
One of the most common practices regarding estimation of forest attributes is
the partitioning of large forested subpopulations into smaller areas of interest to
coincide with specific objectives of present and future forest management. New
estimators are needed to improve estimation of selected forest attributes in small areas
where the...
This dissertation describes the application and development of molecular tools that have great potential for use in studying variation in strawberry germplasm. The first study evaluated 91 microsatellite (simple sequence repeat, SSR) markers for transferability in 22 Fragaria species and their utility in fingerprinting octoploid strawberries. Out of the transferable...
Several states, including Oregon, Massachusetts and California, have been the focus of major health reform efforts in recent years. Oregon utilized a citizen-led commission to generate policy recommendations that led to the enactment of health reform legislation in 2009. This commission helped to create momentum and provide political cover for...