Index Catalog // ScholarsArchive@OSU

A role for CENP-S,T,W,X at Neurospora crassa centromeres?

Creator:: Feng, Mu
Abstract:: During mitosis, sister chromatids are separated by the action of the mitotic spindle. The mitotic spindle attaches to chromosomes at centromeres through a protein complex called the kinetochore. While ~100 proteins have been identified at kinetochores and centromeres, the function of most is poorly understood. The centromere protein, CENP-T (Centromere...
Resource Type:: Presentation

Identification of the Polycomb Repressive Complex 2 in Fungi

Creator:: Pham, Phuong and Freitag, Michael
Abstract:: The process of expressing a gene involves not just binding of proteins and enzymes to DNA to produce first RNA and eventually proteins, but rather association of these transcription factors with chromatin and structural proteins called histones. When histone H3 is trimethylated at lysine 27 to produce H3K27me3, gene silencing...
Resource Type:: Honors College Thesis

Identification of a compound series by high throughput screening capable of reversing the antiviral effect of Ribavirin in tissue culture

Creator:: Gallion, Jonathan
Abstract:: A compound series capable of reversing the antiviral effect of Ribavirin (RBV) against H1N1 was identified from a high throughput screen designed to discover compounds capable of increasing the fidelity of the RNA-dependent RNA polymerase (RDRP) n ribovirus quasispecies. Two lead compounds, RIC-1 (EC50 of 78.4 nM) and RIC-2 (EC50...
Resource Type:: Honors College Thesis

Nongenomic Actions of Steroid Hormones in the Ovine Endometrium

Creator:: Ireton, Kyle E.
Abstract:: The steroid hormone estrogen plays a crucial role in regulating certain mammalian tissues, especially female reproductive systems. Estrogen effects physiological changes in the cell by altering transcription activity for certain target genes, as a consequence of interactions between estradiol-17β (E2) and its nuclear receptor (nER). This mechanism of cellular control...
Resource Type:: Honors College Thesis

Gender-Dependent Mechanisms of Alpha-Tocopherol Protection from Benzo[a]pyrene Exposure in Rats

Creator:: Crimp, Caitlin A.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (B[a]P), are environmental pollutants linked to increased disease susceptibilities. Alpha-Tocopherol (αT) supplementation decreases B[a]P-DNA adducts in smokers, particularly women; but the mechanism is unknown. To test the hypothesis that αT protection from B[a]P exposure is gender-dependent, male and female rats received 7 daily subcutaneous...
Resource Type:: Honors College Thesis

Involvement of PP6 in Dephosphorylation of Bcl11b, a Tumor Suppressor Transcription Factor

Creator:: Parker, Chelsea R.
Abstract:: The purpose of this honors thesis research project is to investigate the molecular causes of childhood and infant T-cell acute lymphoblastic leukemias. T-cells are the work horses of the immune system, and like any organ, must develop properly to be fully functional. Improper development of thymocytes into T-cells can lead...
Resource Type:: Honors College Thesis

The Soul of Global Medicine: Tales from the International Bedside

Creator:: Derrah, Ryan
Abstract:: In his work, The Soul of Medicine: Tales from the Bedside, Dr. Sherwin Nuland utilized narratives from his colleagues detailing their encounters with their most remarkable patients in order to characterize what he refers to as “the soul of medicine”. However, the stories contributed focused on the practice of medicine...
Resource Type:: Honors College Thesis

Oxytocin-dependent MARCKS protein phosphorylation in the ovine endometrium

Creator:: Ireton, Kyle
Abstract:: This item is a powerpoint presentation of an HHMI research project conducted during the summer of 2011 by Kyle Ireton, in partnership with Dr. Fredrick Stormshak. The objective of this study was to identify whether the myristoylated alanine-rich c kinase substrate (MARCKS) protein is phosphorylated in vivo, in response to...
Resource Type:: Presentation

Investigating the Toxicity of Oxygenated Polycyclic Aromatic Hydrocarbons (OPAHs) in Developing Zebrafish

Creator:: Swanson, Annika
Abstract:: The toxicity of a group of oxygenated polycyclic aromatic hydrocarbons (OPAHs) was investigated using embryonic zebrafish. An immediate goal was to determine the relative toxicity of these compounds and to explore the toxicity mechanisms. It is thought that some OPAHs cause toxicity by binding and activating the aryl hydrocarbon receptor...
Resource Type:: Presentation

Removal of Unreacted Dinitrophenyl Hydrazine from Carbonyl Derivatives

Creator:: Barkal, Amira
Abstract:: OSU/HHMI Summer Undergraduate Research Symposium Presentation.
Resource Type:: Presentation

ScholarsArchive@OSU

A role for CENP-S,T,W,X at Neurospora crassa centromeres?

Identification of the Polycomb Repressive Complex 2 in Fungi

Identification of a compound series by high throughput screening capable of reversing the antiviral effect of Ribavirin in tissue culture

Nongenomic Actions of Steroid Hormones in the Ovine Endometrium

Gender-Dependent Mechanisms of Alpha-Tocopherol Protection from Benzo[a]pyrene Exposure in Rats

Involvement of PP6 in Dephosphorylation of Bcl11b, a Tumor Suppressor Transcription Factor

The Soul of Global Medicine: Tales from the International Bedside

Oxytocin-dependent MARCKS protein phosphorylation in the ovine endometrium

Investigating the Toxicity of Oxygenated Polycyclic Aromatic Hydrocarbons (OPAHs) in Developing Zebrafish

Removal of Unreacted Dinitrophenyl Hydrazine from Carbonyl Derivatives

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