Microglia and reactive astrocytes accumulate in the spinal cord of rats expressing the Amyotrophic lateral sclerosis (ALS)-linked SOD1ᴳ⁹³ᴬ mutation. We previously reported that the rapid progression of paralysis in ALS rats is associated with the appearance of prolifer- ative astrocyte-like cells that surround motor neurons. These cells, designated as Aberrant...
BACKGROUND: The wild grass Brachypodium distachyon has emerged as a model system for temperate grasses and
biofuel plants. However, the global analysis of miRNAs, molecules known to be key for eukaryotic gene regulation,
has been limited in B. distachyon to studies examining a few samples or that rely on computational...
The Mongolian Steppe is one of the largest remaining grassland ecosystems. Recent studies have reported widespread
decline of vegetation across the steppe and about 70% of this ecosystem is now considered degraded. Among
the scientific community there has been an active debate about whether the observed degradation is related to...
The exponential growth of the salmonid farming industry during the last 3 decades has created conditions for massive escapes of these exotic species into natural environments in southern Chile. Here, we review and update information about salmonid escapes from 1993 to 2012 and examine their potential environmental, social, and economic...
Background: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease and a risk
factor for cirrhosis, hepatocellular carcinoma and liver failure. Previously, we reported that dietary docosahexaenoic
acid (DHA, 22:6,n-3) was more effective than eicosapentaenoic acid (EPA, 20:5,n-3) at reversing western diet (WD)
induced NASH in LDLR-/-...
Research progress to understand the role of vitamin C (ascorbic acid) in human health has been slow in coming. This is predominantly the result of several flawed approaches to study design, often lacking a full appreciation of the redox chemistry and biology of ascorbic acid. In this review, we summarize...
Metal–insulator–metal diodes with Nb₂O₅ and Ta₂O₅ insulators deposited via atomic layer deposition are investigated. For both Nb₂O₅ and Ta₂O₅, the dominant conduction process is established as Schottky emission at small biases and Frenkel–Poole emission at large biases. Fowler–Nordheim tunneling is not found to play a role in determining current versus...
BACKGROUND: The significance of the serotonergic system in bone physiology and, more specifically, the importance of the five hydroxytryptamine receptor 2A (5HTR2A) in normal osteoblast proliferation have been previously described; however the role of serotonin in osteosarcoma remains unclear. Particularly, the expression and function of 5HTR2A in canine osteosarcoma has...
Bacteria in the class Alphaproteobacteria have a wide variety of lifestyles and physiologies. They include pathogens
of humans and livestock, agriculturally valuable strains, and several highly abundant marine groups. The ancestor of
mitochondria also originated in this clade. Despite significant effort to investigate the phylogeny of the
Alphaproteobacteria with a...
BACKGROUND: Consumption of sugar-sweetened beverage (SSB) has risen over the past two decades, with over 10 million Californians drinking one or more SSB per day. High SSB intake is associated with risk of type 2 diabetes, obesity, hypertension, and coronary heart disease (CHD). Reduction of SSB intake and the potential...