Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
The rate of physician dissatisfaction is steadily rising. Between 2011 and 2012, the number of physicians that would not choose a career in medicine if given the opportunity to decide again increased by 15% (Adams). This discontentment has major repercussions in the midst of the rising need for physicians: it...
The purpose of this study was to investigate the effects of wildfire on soil hydraulic properties of forested hillslopes. The study site was located within the Stouts Creek wildfire, which burned approximately 10,705 ha of forest in southwestern Oregon in summer 2015. Three soil hydraulic properties (soil moisture, unsaturated hydraulic...
Midwives in the Unites States frequently prescribe herbs and other complementary and alternative therapies for the common complaints of pregnancy, labor, and the postpartum period. Although many studies have reported quantitative data on midwives utilization of herbs, this research aims to convey ethnographic information on midwives use, beliefs, and perceptions...
The purpose of this project was to design the 2016 combustion car drivetrain for Global Formula Racing (GFR). The goal of this project was to improve upon the 2015 drivetrain design by reducing complexity, weight, and maintenance time. To reduce complexity the spool was changed to a one piece system...
Current protein immobilization techniques lack defined control over protein orientation. Protein orientation is important for making biosensors and biomaterials that are sensitive and efficient and can be crucial for designing some devices such as immunosensors or direct electron transferring biocells. A new method of protein immobilization is proposed that takes...
Current protein immobilization techniques lack defined control over protein orientation. Protein orientation is important for making biosensors and biomaterials that are sensitive and efficient and can be crucial for designing some devices such as immunosensors or direct electron transferring biocells. A new method of protein immobilization is proposed that takes...
Swelling soils cause millions of dollars of damage to buildings every year in the Unites States alone. One essential piece to understanding these soils is to understand how water moves through them. Hydraulic conductivity is a measure of how easily water flows through a soil. Currently, the most common method...
T. pseudonana biosilica and live cells was explored as a biosensor for detection of the explosive compound 2,4,6-trinitrotoluene (TNT) in aqueous solution. The diatom frustule is an intricately nanostructured, highly porous biogenic silica material derived from the shells of microscopic algae called diatoms. This material emits strong visible blue photoluminescence...