Xenobiotic exposures may induce alternative splicing in the pre-mRNA of nuclear hormone receptor (NHR) genes, yielding unpredictable patterns of gene expression that may promote adverse drug events and promote environmental disease. Informed by observations in the androgen receptor (AR; class I NHR), whereby alternatively-spliced AR transcripts induce ligand-independent hormone signaling...
Aging is a complex biological phenomenon that alters many different physiological processes. Although many age-related phenotypes, such as neurodegeneration, weakening circadian rhythms, and inflammaging, are well-studied, the links between them are not. To elucidate these links we created an inflammation-like state in Drosophila melanogaster by overexpressing Relish (Rel), an NFκB...
This research paper uses data from the World Value Survey to examine the relationship between life satisfactions, perception of freedom, and religious affiliation in The People’s Republic of China, the Republic of Finland, and the United State of America. The paper looks to compare three different countries with vastly different...
The purpose of this thesis was to determine if an underlying biological cause exists for the exuberant reproductive success in free-roaming unowned (FRU) cats. The hypothesis for this thesis was that FRU tom and queen cats have reproductively adapted to man-made sterilization efforts by lowering the age at which they...
Fat Studies (FS) is a new interdisciplinary field that addresses oppression based on body weight, shape, and size as it intersects with oppression based on other areas of difference. As such, FS incorporates a weight-neutral approach to health, Health At Every Size® (HAES), that decries weight bias, promotes body self-acceptance...
Over 70% of the Antarctic krill population exists along the Antarctic Peninsula, a region undergoing rapid climate change. Recent studies have shown a clear correlation between krill recruitment each spring and the timing and coverage of sea ice the winter before, with less sea ice and a shorter duration being...
Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
A novel approach for the colorimetric detection of creatinine in a paper/polycaprolactone hybrid microfluidic device using alkaline3,5-dinitrobenzoate (DNB) is described. The reaction parameters of reagent concentration, alkalinity, and analysis time are optimized for fast reaction times and high color yield. Microfluidic devices incorporating this assay are designed and fabricated to...