Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative...
Abstract: Coastal upwelling zones may be at enhanced risk from ocean acidification as upwelling brings low aragonite saturation state (Ω[subscript Ar]) waters to the surface that are further suppressed by anthropogenic CO₂. Ω[subscript Ar] was calculated with pH, pCO₂, and salinity-derived alkalinity time series data from autonomous pH and pCO₂...