Objective: To examine the pricing trajectories in the United States of disease-modifying therapies (DMT) for multiple sclerosis (MS) over the last 20 years and assess the influences on rising prices.
Methods: We estimated the trend in annual drug costs for 9 DMTs using published drug pricing data from 1993 to...
Carbon nanotubes are the subject of intense interest in virtually every field, from medicine to nano-scale electrical components. Multi-walled nanotubes exhibit a strong nonlinear response to high-field strength terahertz radiation. This research uses terahertz pulses with field strength exceeding 1 MV/cm generated by means of optical rectification utilizing a lithium...
A method for determining bandgap energy using diffuse reflection is presented. The method uses bifurcated fiber optic cables to measure the diffuse reflection of diffusely reflective materials. The absorption spectrum is extrapolated from the diffuse reflection spectrum and used to determine the bandgap of powdered materials. The theory of nonspecular...
Carbon nanotubes are the subject of intense interest in virtually every field, from medicine to
nano-scale electrical components. Multi-walled nanotubes exhibit a strong nonlinear response
to high-field strength terahertz radiation. This research uses terahertz pulses with field strength
exceeding 1 MV/cm generated by means of optical rectification utilizing a lithium...
Mycobacterium avium subsp. hominissuis is an opportunistic pathogen that is associated with biofilm-related infections of the respiratory tract and is difficult to treat. In recent years, extracellular DNA (eDNA) has been found to be a major component of bacterial biofilms, including many pathogens involved in biofilm-associated infections. To date, eDNA...
This project examines the computational fluid dynamics (CFD) model used by Global Formula Racing (GFR) to simulate external aerodynamics for a Formula SAE racecar. It seeks to improve the accuracy of the existing model by changing mesh and physics model parameters. Accuracy of the model is quantified through comparison to...
Pseudomonas aeruginosa is a gram-negative nosocomial pathogenic bacterium known for its resilience against antibiotics. The bacterium infects over 50,000 patients each year in the United States, with 13% of reported cases involving multi-drug-resistant strains of Pseudomonas. This research discovered several fungal natural products with promising activity against Pseudomonas aeruginosa. The...
The Cascade Volcanic Arc has been the subject of extensive study in the past due to its active volcanism and its proximity to metropolitan areas. The triangle formed by the volcanoes Mount Saint Helens, Mount Rainier, and Mount Adams is of particular interest because of this potential danger and the...
Human use of fossil fuels has caused a dramatic shift in the earth’s environment, with global temperatures rising and ecosystem health declining. The need for the human species to reduce our reliance on fossil fuels is apparent. This will be achieved by replacing conventional energy resources with sustainable alternatives, and...
Even though cloudburst events in high mountain areas can be highly destructive and result in significant losses of life, little is known definitively about these flood events. An exact
understanding of the driving processes, typical precipitation rates, and impacts of cloudburst events remain uncertain. This study seeks to advance knowledge...