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Filtering by: Date issued sim 2016-03-30 Degree Level Bachelor's

Exploring the functional effects of Leukemia-promoting natural mutations in the tumor suppressor protein, BCL11B

Creator:

Wisner, Heather

Abstract:

Thymocytes, cells of the thymus gland, undergo developmental steps that enable them to properly mature into T-cells. Errors in gene expression may lead to improper maturation and potentially mass proliferation of dysfunctional thymocytes, a hallmark of leukemia or lymphoma. BCL11B is a tumor suppressor and transcriptional regulatory protein that is...

Resource Type:

Honors College Thesis