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Filtering by: Creator Sterba, George R. Degree Field BioResource Research License Attribution-NonCommercial-ShareAlike 4.0 (CC BY-NC-SA 4.0)

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Creator:

Sanchez, Karina M.

Abstract:

Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...

Resource Type:

Undergraduate Thesis

Full Text:

′-Hydroxyacetanilide. Chem Res Toxicol 29:1857–1864, American Chemical Society 11. Tan Q, Zhu R, Li H, Wang F, Yan M