Index Catalog // ScholarsArchive@OSU

Method development in in vitro immune response

Creator:: Huber, Jacob
Abstract:: The AhR is a ligand-activated transcription factor that mediates the potent immunosuppressive effects of TCDD. AhR-dependent changes in gene expression appear to alter the differentiation of CD4+ T cells to induce a population of CD4+CD25+ T regulatory cells (Tregs) that suppress the immune response. Ascertaining if and how the AhR...
Resource Type:: Undergraduate Thesis and Presentation

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Creator:: Luo, Yun L.
Abstract:: Polycyclic Aromatic Hydrocarbons (PAHs) have been studied for their carcinogenic toxicity. PAHs are formed by incomplete carbon combustion. Benzo[a]pyrene (BaP) is an IARC classified Class 1 Human carcinogenic PAH. New studies are conducted to gain a better understanding of PAHs and how to reduce exposure. Glutathione S-transferase M 1 (GSTM1...
Resource Type:: Honors College Thesis
Full Text:: Genotyping Cytochrome P450 1B1*3(Phase I) and

Gene regulatory mechanisms of the lncRNA Fendrr

Creator:: Koehler, Monika
Abstract:: Embryonic development, where organs and major structures begin to develop, requires precise coordination of numerous gene regulatory pathways. Fendrr is an long non-coding RNA (lncRNA) that plays a role in regulating gene expression in mesodermal tissues during early embryonic development in mouse. The lateral plate mesoderm (LPM) is an earlier...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: . 25 Acknowledgement: I would like to give a big thank you to Dr. David Hendrix for his

Low Cloud Point Biodiesel

Creator:: Johnson, Shanti Christopher
Abstract:: The synergetic interplay between the removal of saturated methyl esters and the addition of deoxygenated fatty acids on depressing the cloud point temperature of biodiesel was investigated in this study. Canola biodiesel was produced in batch as a standard with a cloud point of 1.37 +/- 6.3°C. Saturated methyl esters...
Resource Type:: Undergraduate Thesis
Full Text:: Johnson Low cloud Point Biodiesel 9/4/2014 13 Acknowledgements I would like to thank Dr. David

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis
Full Text:: . Abstract approved: ______________________________________________________ David E. Williams

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Creator:: Raymundo, Wilfrido E.
Abstract:: Testing the many potential chemoprevention agents from dietary sources in animal or human models is expensive and takes a long time. In vitro models can be useful for screening the right compounds to use in larger studies. We tested the MatTek™ EpiIntestinal™ small intestine epithelial 3D cell culture model for...
Resource Type:: Undergraduate Thesis
Full Text:: : ____________________________________________________ _______________ David Williams, Department of Environmental and Molecular Toxicology

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Creator:: Mans, Michael-Andres D.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Resource Type:: Undergraduate Thesis
Full Text:: _____________________________________________________ _______________ David Williams, Environmental and Molecular Toxicology

Effects of Contemporary Forest Practices on Stream Nutrients, Temperature, and Periphyton in Small Headwater Streams

Creator:: Pimont, Cedric
Abstract:: Forest harvest practices can impact nutrient concentrations and stream temperatures, altering aquatic ecosystems. To better inform future sustainable forest resource management practices, quantifying the impact of current practices on water quality, particularly in headwater streams is important. In this study, I quantified monthly nitrate-nitrite (N) and orthophosphate (P) concentrations, 7-day...
Resource Type:: Honors College Thesis
Full Text:: study, I quantified monthly nitrate-nitrite (N) and orthophosphate (P) concentrations, 7-day maximum

De novo Discovery of Novel Long Noncoding RNAs in the North American Beaver

Creator:: Kashyap, Amita
Abstract:: Long noncoding RNAs (lncRNAs) are RNA molecules that are at least 200 nucleotides long and do not encode proteins. lncRNAs have roles in gene regulation, chromatin epigenetics, and molecular scaffolding. In light of mounting evidence implicating species-specific noncoding RNAs and gene regulatory mechanisms in species adaptations, it is reasonable to...
Resource Type:: Honors College Thesis
Full Text:: Cutting David Shepherdson 11/29/2017 Amita Kashyap, Ramsey Lab THANK YOU 11/29/2017 Amita Kashyap

Preliminary Evidence that the Microbial Community may Produce Aliphatic Constituents and Induce Soil Water Repellency as a Response to Desiccation

Creator:: Chilcote, Emma T.
Abstract:: Soil water repellency is one cause of rill soil erosion and overland flow that results in the loss of fertile topsoil. Previous research suggests that since microbial growth depends on temperature/moisture and follows diurnal and seasonal cycles, a biological mechanism would be able to explain the observed seasonality and climate...
Resource Type:: Honors College Thesis
Full Text:: , Mentor, representing Department of Crop and Soil Science David Myrold, Secondary Mentor

ScholarsArchive@OSU

Method development in in vitro immune response

Genotyping Cytochrome P450 1B1*3(Phase I) and Glutathione S-transferase Mu 1 null (Phase II), Metabolizing Enzymes in a [14C]Benzo[a]pyrene Human Micro Dosing Study

Gene regulatory mechanisms of the lncRNA Fendrr

Low Cloud Point Biodiesel

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

MatTek™ EpiIntestinal™ a 3D Small Intestine Epithelial Cell Culture Model For In Vitro Screening in Dietary Chemopreventive Agents

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Effects of Contemporary Forest Practices on Stream Nutrients, Temperature, and Periphyton in Small Headwater Streams

De novo Discovery of Novel Long Noncoding RNAs in the North American Beaver

Preliminary Evidence that the Microbial Community may Produce Aliphatic Constituents and Induce Soil Water Repellency as a Response to Desiccation

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