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Creator:: Stevens, Danielle M.
Abstract:: Carbonic anhydrases are ubiquitous enzymes that catalyze the reverse hydration and dehydration of carbon dioxide and bicarbonate respectively. A variety of tumors in humans show overexpression of human carbonic anhydrase II (HCA II) leading to an acidic breakdown of carbon dioxide into bicarbonate. While a variety of drug inhibitors exist,...
Resource Type:: Research Paper
Full Text:: phenylalanine with p-bromophenylalanine (pBrF) has a slight decrease in enzymatic activity while the exchange

Creator:: Stevens, Danielle M.
Abstract:: Bacteria are critical to the health of eukaryotes and the ecosystems in which they persist. Some symbiotic interactions are mutualistic in which both microbe and host benefit from the partnership. Other interactions are parasitic, and the microbe typically benefits at a cost to the host. Rhodococcus is a genus of...
Resource Type:: Undergraduate Thesis
Full Text:: . J. Bacteriol. 176: 2492-2501. Dhandapani, P., Song, J., Novak, O., and Jameson, P. E. 2017

Creator:: Geisler, Mark S.
Abstract:: Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
Resource Type:: Honors College Thesis
Full Text:: , Madison Esposito, Steven Friedman, Rodrigo Gonçalves, and Michael Freitag conceived and designed the

Creator:: Tong, Tony T.
Abstract:: Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
Resource Type:: Honors College Thesis
Full Text:: chauffeur. I doubt anyone has done this, but I’d also like to acknowledge Steven P. Jobs and his team at

Creator:: Gallion, Jonathan
Abstract:: A compound series capable of reversing the antiviral effect of Ribavirin (RBV) against H1N1 was identified from a high throughput screen designed to discover compounds capable of increasing the fidelity of the RNA-dependent RNA polymerase (RDRP) n ribovirus quasispecies. Two lead compounds, RIC-1 (EC50 of 78.4 nM) and RIC-2 (EC50...
Resource Type:: Honors College Thesis

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