Index Catalog // ScholarsArchive@OSU

Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

Creator:: Estelle, Aidan B.
Abstract:: Interactions between proteins are essential to life, driving and regulating a majority of processes within all living cells. Study of protein-protein interactions reveals that some proteins act as hubs within networks of interactions, binding to many partner proteins. These hubs therefore are of particular importance to understanding protein function, interwoven...
Resource Type:: Dissertation
Full Text:: our countless conversations about my work over the years. Thank you, Claudia, for donating your time

Biophysical analyses of peroxiredoxins and a partner reductase

Creator:: Hall, Andrea Renée
Abstract:: Peroxiredoxins (Prxs) are dominant peroxide-reducing enzymes with two important roles: they protect all organisms from oxidative damage induced by peroxides, and in eukaryotes, they participate in hydrogen peroxide signaling pathways. This dissertation presents studies aimed at the biophysical characterization of select Prxs and a Prx reductase to elucidate their structure-function...
Resource Type:: Dissertation
Full Text:: Trempy, Claudia Maier and Martin Schuster for your interest in my development as a scientist. I

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Creator:: Gómez Ramirez, Luis A.
Abstract:: Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...
Resource Type:: Dissertation
Full Text:: research committee, Drs. Claudia S. Maier, Balz Frei, Joseph Beckman and Adam Higgins not only for

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:: Otto, Shauna C.
Abstract:: Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Shauna C. Otto for

Regulation of phosphofructokinase by reversible inactivation

Creator:: Zhao, Zhizhuang
Abstract:: The interaction of skeletal muscle phosphofructokinase with a variety of acidic proteins including calmodulin and troponin C and with nucleic acids (RNA and DNA) is manifest in a reversible, time-dependent loss of catalytic activity. The inactivation is affected by a number of factors. Substrates (fructose-6-phosphate and ATP), positive effectors (fructose-2,6-bisphosphate,...
Resource Type:: Dissertation
Full Text:: phosphofructokinase with a variety of acidic proteins including calmodulin and troponin C and with nucleic acids

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:: Campbell, Yan
Abstract:: The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Resource Type:: Dissertation
Full Text:: proteolysis of the variable C-terminal end from hCAP18 (11). It is released from the conserved N-terminal

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Creator:: Guo, Chunxiao
Abstract:: Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
Resource Type:: Dissertation
Full Text:: ................................................................................................ 97 Figure 5.1. C/EBPs activate CAMP luciferase reporter

Calculations relating to the structure of biopolymers

Creator:: Rose, George David
Resource Type:: Dissertation
Full Text:: dipeptide gly-ala 9 2 Sterically allowed positions for the first post-helical residue adjoining the C

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Creator:: Logan, Isabelle E.
Abstract:: Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Resource Type:: Dissertation
Full Text:: . Jan F. Stevens provided scientific and material support. Claudia S. Maier and Jan F. Stevens

Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

Creator:: Rhoads, Timothy W.
Abstract:: Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
Resource Type:: Dissertation
Full Text:: spectrometry data in Chapter 2. Daniel Zollinger provided the recombinant protein used in Chapter 2. Claudia

ScholarsArchive@OSU

Specificity, Allostery, and Multivalency in Binding to the Hub Protein LC8

Biophysical analyses of peroxiredoxins and a partner reductase

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Regulation of phosphofructokinase by reversible inactivation

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Calculations relating to the structure of biopolymers

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Measuring protein metal binding via mass spectrometry : copper, zinc superoxide dismutase and amyotrophic lateral sclerosis

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